RHOB and RHPN2

Number of citations of the paper that reports this interaction (PMID 12473120)
4

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		RHOB	RHPN2
Gene Name		ras homolog family member B	rhophilin, Rho GTPase binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Early Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Late Endosome Membrane Cleavage Furrow Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Transformed Cell Apoptotic Process Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Endosome To Lysosome Transport Platelet Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation	Signal Transduction
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Systemic sclerosis ( 21750679)	Colorectal cancer ( 19011631) Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: ARHGDIG ARHGEF3 CIT FNTA PDE6D PGGT1B PPP2CA RHPN2 TNFAIP1	6 interactors: KRT18 RARG RHOA RHOB SMURF1 TGFBR1
Entrez ID		388	85415
HPRD ID		01321	10192
Ensembl ID		ENSG00000143878	ENSG00000131941
Uniprot IDs		P62745	Q8IUC4
PDB IDs		2FV8	2VSV
Enriched GO Terms of Interacting Partners?		Protein Geranylgeranylation Protein Prenylation Regulation Of Catalytic Activity Response To Stimulus Rho Protein Signal Transduction Apoptotic Process Programmed Cell Death Positive Regulation Of Tubulin Deacetylation Cell Death Death Regulation Of Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Receptor Activity Regulation Of DNA Replication Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Protein Farnesylation Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Tubulin Deacetylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Deacetylase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Neurotransmitter Receptor Metabolic Process Regulation Of Signaling Ras Protein Signal Transduction Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Dendrite Morphogenesis Cellular Macromolecule Catabolic Process Intracellular Signal Transduction Cellular Protein Modification Process Mitotic Nuclear Envelope Reassembly Enzyme Linked Receptor Protein Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Heterotrimerization Nuclear Envelope Reassembly Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Signal Transduction Stress Fiber Assembly Positive Regulation Of Hydrolase Activity Negative Regulation Of Dendrite Development Regulation Of Rho Protein Signal Transduction Negative Regulation Of Cell Development Signaling Negative Regulation Of Epithelial To Mesenchymal Transition Cell Communication	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Chondrocyte Differentiation Cellular Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cartilage Development Anatomical Structure Morphogenesis Response To Organic Substance Anatomical Structure Development Rho Protein Signal Transduction Regulation Of Chondrocyte Differentiation Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Developmental Process Signaling Regulation Of Apoptotic Process Regulation Of Cartilage Development Cell Communication Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Cell Death Skeletal System Development Golgi To Plasma Membrane CFTR Protein Transport Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cytokinesis Wound Healing Response To Growth Factor Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Cell Differentiation Positive Regulation Of Cell Death Tissue Development Cell Activation Cell Development Cytoplasmic Transport Response To Wounding Cellular Response To Stimulus Growth Plate Cartilage Chondrocyte Growth Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Intracellular Protein Transport Growth Plate Cartilage Chondrocyte Development Harderian Gland Development
Tagcloud ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts
Tagcloud (Difference) ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts
Tagcloud (Intersection) ?