RHOB and TNFAIP1

Number of citations of the paper that reports this interaction (PMID 19637314)
5

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RHOB	TNFAIP1
Gene Name		ras homolog family member B	tumor necrosis factor, alpha-induced protein 1 (endothelial)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Early Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Late Endosome Membrane Cleavage Furrow Extracellular Vesicular Exosome	Nucleolus Cytoplasm Endosome Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Ubiquitin-protein Transferase Activity Protein Binding GTP-Rho Binding Protein Domain Specific Binding
	Biological Process	Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Transformed Cell Apoptotic Process Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Endosome To Lysosome Transport Platelet Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation	DNA Replication Apoptotic Process Immune Response Embryo Development Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Systemic sclerosis ( 21750679)
Protein-Protein Interactions		9 interactors: ARHGDIG ARHGEF3 CIT FNTA PDE6D PGGT1B PPP2CA RHPN2 TNFAIP1	21 interactors: ARMC7 ARNT CAPN7 CARD9 CSNK2B CUL3 EPHA2 EPM2AIP1 EXOSC5 HAT1 KCTD13 KDM1A POLR1C PSMA1 RHOA RHOB RIN3 STK16 SUV39H1 SVIL ZDHHC17
Entrez ID		388	7126
HPRD ID		01321	01856
Ensembl ID		ENSG00000143878	ENSG00000109079
Uniprot IDs		P62745	Q13829
PDB IDs		2FV8
Enriched GO Terms of Interacting Partners?		Protein Geranylgeranylation Protein Prenylation Regulation Of Catalytic Activity Response To Stimulus Rho Protein Signal Transduction Apoptotic Process Programmed Cell Death Positive Regulation Of Tubulin Deacetylation Cell Death Death Regulation Of Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Receptor Activity Regulation Of DNA Replication Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Protein Farnesylation Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Tubulin Deacetylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Deacetylase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Neurotransmitter Receptor Metabolic Process Regulation Of Signaling Ras Protein Signal Transduction Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Dendrite Morphogenesis Cellular Macromolecule Catabolic Process Intracellular Signal Transduction Cellular Protein Modification Process Mitotic Nuclear Envelope Reassembly Enzyme Linked Receptor Protein Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Heterotrimerization Nuclear Envelope Reassembly Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Signal Transduction Stress Fiber Assembly Positive Regulation Of Hydrolase Activity Negative Regulation Of Dendrite Development Regulation Of Rho Protein Signal Transduction Negative Regulation Of Cell Development Signaling Negative Regulation Of Epithelial To Mesenchymal Transition Cell Communication	Regulation Of Signal Transduction Regulation Of Signaling Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokinesis Regulation Of Cytokinesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Cycle Process Positive Regulation Of Hormone Biosynthetic Process Stress Fiber Assembly Positive Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Division Response To Stress Negative Regulation Of Rho Protein Signal Transduction Regulation Of Cellular Process Regulation Of Hormone Biosynthetic Process Regulation Of Epithelial Cell Migration Cell Morphogenesis Involved In Differentiation Axon Guidance Negative Regulation Of Intracellular Signal Transduction Chromatin Silencing Regulation Of Hormone Metabolic Process Locomotion Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Erythrocyte Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To External Stimulus Cell Cycle Regulation Of Cell Cycle Process Regulation Of Gene Expression, Epigenetic Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Cycle Axonogenesis Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Primitive Erythrocyte Differentiation Notochord Cell Development Viral Process Movement Of Cell Or Subcellular Component Axon Development Rho Protein Signal Transduction Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Cell Division
Tagcloud ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts	adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical inducible invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation
Tagcloud (Difference) ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts	adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical inducible invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation
Tagcloud (Intersection) ?