FOXK2 and IRF2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		FOXK2	IRF2
Gene Name		forkhead box K2	interferon regulatory factor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol Focal Adhesion
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways			Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: IL2 IRF2	22 interactors: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 FOXK2 HMGB1 HMGN1 IRF1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA STAT1
Entrez ID		3607	3660
HPRD ID		00982	00962
Ensembl ID		ENSG00000141568	ENSG00000168310
Uniprot IDs		Q01167	P14316
PDB IDs		1JXS 2C6Y
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Immunoglobulin Secretion Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Interleukin-17 Production Negative Regulation Of B Cell Apoptotic Process Regulation Of Immunoglobulin Secretion Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of B Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Heart Contraction Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Isotype Switching Positive Regulation Of Dendritic Spine Development Positive Regulation Of Tissue Remodeling Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Immune Response Regulation Of Activated T Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Dendritic Spine Development Positive Regulation Of Macromolecule Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Interferon-gamma Production Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of B Cell Proliferation Positive Regulation Of Dendrite Development Natural Killer Cell Activation Positive Regulation Of JAK-STAT Cascade Regulation Of Lymphocyte Apoptotic Process Regulation Of Tissue Remodeling Regulation Of DNA Recombination Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Positive Regulation Of B Cell Activation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of Interferon-gamma Production Regulation Of JAK-STAT Cascade Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of Cellular Metabolic Process	Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Regulation Of Gene Expression RNA Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Immune Response Negative Regulation Of Biosynthetic Process Defense Response Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Protein Metabolic Process Apoptotic Process Programmed Cell Death Response To External Stimulus Biosynthetic Process Cell Death Death Regulation Of Interleukin-12 Production Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Viral Process
Tagcloud ?		attenuation bcl2 brdu compensating dramatic emphasized forkhead gadd45alpha gadd45gamma gadd45s inc indicative iodide knockdown noxa p70s6k partly periodicals physiol potentiated propidium puma rapamycin requirement synergistically tgfbeta ubiquitously upregulating wiley	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		attenuation bcl2 brdu compensating dramatic emphasized forkhead gadd45alpha gadd45gamma gadd45s inc indicative iodide knockdown noxa p70s6k partly periodicals physiol potentiated propidium puma rapamycin requirement synergistically tgfbeta ubiquitously upregulating wiley	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?