IGKC and CD40LG

Number of citations of the paper that reports this interaction (PMID 11525169)
6

Data Source:
HPRD (in vitro)

		IGKC	CD40LG
Gene Name		immunoglobulin kappa constant	CD40 ligand
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Antigen Binding	Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding
	Biological Process	Retina Homeostasis Receptor-mediated Endocytosis Immune Response Complement Activation Complement Activation, Classical Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Immune Response	Inflammatory Response Leukocyte Cell-cell Adhesion Platelet Activation B Cell Differentiation Positive Regulation Of Interleukin-12 Production B Cell Proliferation Negative Regulation Of Apoptotic Process Isotype Switching Immunoglobulin Secretion Regulation Of Immune Response Regulation Of Immunoglobulin Secretion Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CD40LG IGHG1 MLH1 SMARCD1	6 interactors: CD40 CD5L IGHG1 IGKC RNF128 TP53
Entrez ID		3514	959
HPRD ID		00921	02311
Ensembl ID			ENSG00000102245
Uniprot IDs			P29965 Q3L8U2
PDB IDs			1ALY 1I9R 3LKJ 3QD6
Enriched GO Terms of Interacting Partners?		Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Isotype Switching Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Immunoglobulin Production Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Leukocyte Activation Involved In Immune Response B Cell Activation Negative Regulation Of Mitotic Recombination DNA Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Immune Response Immunoglobulin Secretion Spindle Midzone Assembly Lymphocyte Activation Chromatin-mediated Maintenance Of Transcription Positive Regulation Of Endothelial Cell Apoptotic Process Resolution Of Meiotic Recombination Intermediates Somatic Hypermutation Of Immunoglobulin Genes Leukocyte Activation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Immunoglobulin Secretion Nucleosome Disassembly Immune System Process Positive Regulation Of Gene Expression, Epigenetic Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Cell Activation Immune System Development Metaphase Plate Congression Regulation Of Endothelial Cell Apoptotic Process B Cell Proliferation Establishment Of Chromosome Localization Reciprocal Meiotic Recombination Positive Regulation Of Interleukin-12 Production Regulation Of Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Synapsis Mismatch Repair Homologous Chromosome Segregation	Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response Immune Response-regulating Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Response To Stress Positive Regulation Of Immune Response Leukocyte Proliferation Endocytosis Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Complement Activation Positive Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Helicase Activity Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Immune System Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Peptidyl-tyrosine Phosphorylation Humoral Immune Response Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Isotype Switching To IgG Isotypes Mitochondrial DNA Repair Phagocytosis Leukocyte Mediated Immunity Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Fc Receptor Signaling Pathway Adaptive Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Oxidative Stress-induced Premature Senescence Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Protein Kinase C Signaling ER Overload Response Negative Regulation Of Macroautophagy Positive Regulation Of Endothelial Cell Apoptotic Process Stress-induced Premature Senescence
Tagcloud ?		anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 cd8a ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable	admixed ancestry aspirin cigarette comparisons contributing contributor hispanic lifestyle mediators menopausal na nhw padj partp regular rs4149578 rs5030728 rs7696175 steroidal tlr tlr1 tlr3 tlr4 tnfrsf1a tnfsf1a toll tra2 traf2
Tagcloud (Difference) ?		anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 cd8a ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable	admixed ancestry aspirin cigarette comparisons contributing contributor hispanic lifestyle mediators menopausal na nhw padj partp regular rs4149578 rs5030728 rs7696175 steroidal tlr tlr1 tlr3 tlr4 tnfrsf1a tnfsf1a toll tra2 traf2
Tagcloud (Intersection) ?