HTR3A and HSPA5

Number of citations of the paper that reports this interaction (PMID 12359150)
16

Data Source:
HPRD (in vivo, in vitro)

		HTR3A	HSPA5
Gene Name		5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Neuronal Cell Body Postsynaptic Membrane	Nucleus Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Serotonin Receptor Activity Serotonin-activated Cation-selective Channel Activity Voltage-gated Potassium Channel Activity Serotonin Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Ribosome Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	Transport Serotonin Receptor Signaling Pathway Synaptic Transmission Digestion Ion Transmembrane Transport Response To Cocaine Response To Ethanol Transmembrane Transport Cellular Response To Growth Factor Stimulus Potassium Ion Transmembrane Transport	Platelet Degranulation ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Blood Coagulation Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Platelet Activation Positive Regulation Of Cell Migration ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Interleukin-4 Toxin Transport
Pathways		Ion channel transport Ligand-gated ion channel transport	Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System
Drugs		Ziprasidone Olanzapine Clozapine Mirtazapine Palonosetron Cisapride Procaine Rocuronium Dolasetron Granisetron Ondansetron Alosetron Memantine Chloroprocaine Tubocurarine Quetiapine Aripiprazole Tapentadol	Antihemophilic Factor
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CANX HSPA5	53 interactors: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HSPBP1 HTR3A ID2 IGHM KRT14 KRT18 KRT8 LCT LDLR METTL21A MTNR1A MTNR1B NDRG1 PAWR PCSK7 PRNP PSME3 RPN1 SEC61A1 SH3BP4 SIL1 SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBQLN4 VHL VWF YWHAB
Entrez ID		3359	3309
HPRD ID		08917	00682
Ensembl ID		ENSG00000166736	ENSG00000044574
Uniprot IDs		B4E398 P46098	P11021
PDB IDs			3IUC 3LDL 3LDN 3LDO 3LDP
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Folding In Endoplasmic Reticulum Cerebellum Structural Organization Secretion By Cell Secretion ER Overload Response Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Antibiotic Anatomical Structure Arrangement Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Synaptic Vesicle Endocytosis Clathrin-mediated Endocytosis Synaptic Vesicle Recycling Cerebellar Purkinje Cell Layer Development Substantia Nigra Development ER-associated Ubiquitin-dependent Protein Catabolic Process Toxin Transport Cellular Response To Interleukin-4 Vesicle-mediated Transport Response To Interleukin-4 Cerebellum Morphogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Hindbrain Morphogenesis Positive Regulation Of Nuclease Activity Chaperone-mediated Protein Folding Response To Antibiotic Cerebellar Cortex Development Platelet Degranulation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization Midbrain Development Establishment Of Localization In Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Protein N-linked Glycosylation Via Asparagine Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Synaptic Vesicle Transport ER-nucleus Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Topologically Incorrect Protein Cerebellum Development Protein N-linked Glycosylation Protein Secretion Cellular Localization Protein Localization To Endoplasmic Reticulum	Response To Stimulus Cellular Response To Stimulus Apoptotic Signaling Pathway Response To Stress Blood Coagulation, Intrinsic Pathway Cell Activation Signal Transduction Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Signaling Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Death Death Cell Communication Platelet Activation Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Cellular Metabolic Process Protein Oligomerization Hemostasis Response To External Stimulus Cellular Response To Organic Substance Protein Folding Regulation Of Lipid Metabolic Process Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Protein Metabolic Process Platelet Degranulation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Regulation Of Cholesterol Homeostasis Hepatocyte Apoptotic Process Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Receptor Signaling Pathway Axonogenesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Stress Cell Development Anatomical Structure Morphogenesis
Tagcloud ?		6e addiction addicts adh7 adra1a avpr1a chrm2 corroborates dbi decarboxylase diazepam drd1 extends gabrb3 gad1 gad2 glutamic grin2a heroin methadone nominal rs1071502 rs1366076 rs4587976 seventeen slc29a1 uncorrected vasopressin wise	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Difference) ?		6e addiction addicts adh7 adra1a avpr1a chrm2 corroborates dbi decarboxylase diazepam drd1 extends gabrb3 gad1 gad2 glutamic grin2a heroin methadone nominal rs1071502 rs1366076 rs4587976 seventeen slc29a1 uncorrected vasopressin wise	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Intersection) ?