HTR3A and CANX

Number of citations of the paper that reports this interaction (PMID 12359150)
16

Data Source:
HPRD (in vitro, in vivo)

		HTR3A	CANX
Gene Name		5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	calnexin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Neuronal Cell Body Postsynaptic Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Receptor Activity Serotonin Receptor Activity Serotonin-activated Cation-selective Channel Activity Voltage-gated Potassium Channel Activity Serotonin Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Transport Serotonin Receptor Signaling Pathway Synaptic Transmission Digestion Ion Transmembrane Transport Response To Cocaine Response To Ethanol Transmembrane Transport Cellular Response To Growth Factor Stimulus Potassium Ion Transmembrane Transport	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis
Pathways		Ion channel transport Ligand-gated ion channel transport	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs		Ziprasidone Olanzapine Clozapine Mirtazapine Palonosetron Cisapride Procaine Rocuronium Dolasetron Granisetron Ondansetron Alosetron Memantine Chloroprocaine Tubocurarine Quetiapine Aripiprazole Tapentadol	Antihemophilic Factor Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CANX HSPA5	42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR
Entrez ID		3359	821
HPRD ID		08917	00252
Ensembl ID		ENSG00000166736	ENSG00000127022
Uniprot IDs		B4E398 P46098	P27824
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Folding In Endoplasmic Reticulum Cerebellum Structural Organization Secretion By Cell Secretion ER Overload Response Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Antibiotic Anatomical Structure Arrangement Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Synaptic Vesicle Endocytosis Clathrin-mediated Endocytosis Synaptic Vesicle Recycling Cerebellar Purkinje Cell Layer Development Substantia Nigra Development ER-associated Ubiquitin-dependent Protein Catabolic Process Toxin Transport Cellular Response To Interleukin-4 Vesicle-mediated Transport Response To Interleukin-4 Cerebellum Morphogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Hindbrain Morphogenesis Positive Regulation Of Nuclease Activity Chaperone-mediated Protein Folding Response To Antibiotic Cerebellar Cortex Development Platelet Degranulation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization Midbrain Development Establishment Of Localization In Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Protein N-linked Glycosylation Via Asparagine Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Synaptic Vesicle Transport ER-nucleus Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Topologically Incorrect Protein Cerebellum Development Protein N-linked Glycosylation Protein Secretion Cellular Localization Protein Localization To Endoplasmic Reticulum	Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization
Tagcloud ?		6e addiction addicts adh7 adra1a avpr1a chrm2 corroborates dbi decarboxylase diazepam drd1 extends gabrb3 gad1 gad2 glutamic grin2a heroin methadone nominal rs1071502 rs1366076 rs4587976 seventeen slc29a1 uncorrected vasopressin wise	5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Difference) ?		6e addiction addicts adh7 adra1a avpr1a chrm2 corroborates dbi decarboxylase diazepam drd1 extends gabrb3 gad1 gad2 glutamic grin2a heroin methadone nominal rs1071502 rs1366076 rs4587976 seventeen slc29a1 uncorrected vasopressin wise	5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Intersection) ?