HTR2B and SNTA1

Number of citations of the paper that reports this interaction (PMID 15123239)
9

Data Source:
BioGRID (unspecified method)

		HTR2B	SNTA1
Gene Name		5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	syntrophin, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Neuron Projection Synapse	Intracellular Cytoplasm Cytoskeleton Syntrophin Complex Lateral Plasma Membrane Cell Junction Neuromuscular Junction Sarcolemma Protein Complex Postsynaptic Membrane
	Molecular Function	G-protein Alpha-subunit Binding Serotonin Receptor Activity Ras GTPase Activator Activity Drug Binding Serotonin Binding	Actin Binding Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation G-protein Coupled Receptor Internalization Heart Morphogenesis Cardiac Muscle Hypertrophy CGMP Biosynthetic Process Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Behavior Positive Regulation Of Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Phosphatidylinositol 3-kinase Signaling Intestine Smooth Muscle Contraction Phosphorylation Calcium-mediated Signaling Positive Regulation Of Ras GTPase Activity Vasoconstriction Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Embryonic Morphogenesis Positive Regulation Of Cytokine Secretion Regulation Of Behavior Positive Regulation Of Nitric-oxide Synthase Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Negative Regulation Of Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Temperature Stimulus	Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Muscle Contraction Neuromuscular Junction Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Eletriptan Methysergide Cabergoline Ropinirole Dihydroergotamine Pramipexole Triflupromazine Fenfluramine Lisuride Apomorphine Minaprine Tegaserod Doxepin Pergolide Bromocriptine Chlorprothixene Clomipramine 3,4-Methylenedioxymethamphetamine Asenapine
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		4 interactors: GNA11 GNAQ LNX1 SNTA1	72 interactors: ABCA1 ABCC4 ACTA2 ADAMTS6 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B BAI1 BAI2 BAI3 C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6
Entrez ID		3357	6640
HPRD ID		03077	03009
Ensembl ID		ENSG00000135914	ENSG00000101400
Uniprot IDs		P41595	B4DX40 Q13424
PDB IDs		4IB4
Enriched GO Terms of Interacting Partners?		Action Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Regulation Of Developmental Pigmentation Regulation Of Membrane Potential Dopamine Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Pigmentation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Epithelial Cell Differentiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Negative Regulation Of Peptidyl-cysteine S-nitrosylation Neuron Remodeling Blood Coagulation Hemostasis Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To PH Maternal Behavior Heart Development Skeletal System Development Ventricular Cardiac Muscle Cell Action Potential Regulation Of Body Fluid Levels Wound Healing Regulation Of Membrane Repolarization Regulation Of Catenin Import Into Nucleus Cardiac Muscle Cell Action Potential Involved In Contraction Cell Activation Neuron Maturation Response To Wounding Regulation Of Sodium Ion Transmembrane Transport Response To PH Forebrain Neuron Development Cardiac Muscle Cell Action Potential Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cardiac Muscle Cell Contraction Cardiovascular System Development Negative Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Neuromuscular Junction Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Vasoconstriction Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Regulation Of Sodium Ion Transport Embryonic Digit Morphogenesis	Cell-cell Signaling Synaptic Transmission Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Muscle System Process Muscle Contraction Regulation Of Heart Contraction G-protein Coupled Receptor Signaling Pathway Metal Ion Transport Ion Transport Regulation Of Muscle Contraction Blood Circulation Negative Regulation Of Adrenergic Receptor Signaling Pathway Monovalent Inorganic Cation Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cation Transport Regulation Of Striated Muscle Contraction Cell Surface Receptor Signaling Pathway Cation Transmembrane Transport Transmembrane Transport Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Homeostasis Positive Regulation Of Cell Proliferation Ion Transmembrane Transport Potassium Ion Import Regulation Of Phosphorus Metabolic Process Behavior Response To Stimulus Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transport CGMP Metabolic Process Positive Regulation Of Ion Transport Response To Drug Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Body Fluid Levels Multicellular Organismal Response To Stress Response To Stress Cellular Response To Stimulus
Tagcloud ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Difference) ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Intersection) ?