HOXB9 and TAL1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HOXB9	TAL1
Gene Name		homeobox B9	T-cell acute lymphocytic leukemia 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion	Histone Deacetylase Complex Nuclear Chromatin Nucleus Transcription Factor Complex Lsd1/2 Complex
	Molecular Function	Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Transcription, DNA-templated Anterior/posterior Pattern Specification Mammary Gland Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Skeletal System Development Canonical Wnt Signaling Pathway Cell Chemotaxis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Locomotory Behavior Spinal Cord Association Neuron Differentiation Hemopoiesis Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Proliferation Erythrocyte Maturation Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Chromatin Assembly Or Disassembly Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Regulation Of Stem Cell Maintenance
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: BTG1 BTG2 CALCOCO2 CREBBP EP300 GOLGA2 HOPX ING4 KRTAP10-9 KRTAP4-12 KRTAP5-9 MDFI MID2 MYBBP1A PHTF1 PNMA1 RBPMS SAT1 SOX15 SPZ1 TAL1 TRIP6 ZNF408	23 interactors: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STUB1 TCF3 TCF4 ZHX1
Entrez ID		3219	6886
HPRD ID		00852	01753
Ensembl ID		ENSG00000170689	ENSG00000162367
Uniprot IDs		B3KPJ1 P17482	P17542
PDB IDs			2YPA 2YPB
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated N-terminal Peptidyl-lysine Acetylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Protein Amino Acid Acetylation Regulation Of Binding Histone Acetylation Signal Transduction By P53 Class Mediator Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Response To Stress Regulation Of Protein Binding Chromatin Organization Regulation Of Cellular Response To Heat Histone Modification Regulation Of Protein Import Into Nucleus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Localization To Nucleus Regulation Of Cellular Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Wound Healing	Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Embryo Development Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Binding Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Blood Coagulation Hemostasis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromosome Organization Negative Regulation Of Binding Regulation Of Hormone Metabolic Process Regulation Of Erythrocyte Differentiation Regulation Of Body Fluid Levels Biosynthetic Process Wound Healing Hemopoiesis Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Histone Modification Immune System Process
Tagcloud ?		10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4	activates arrest causes complexed contribute e2a expressing fusion heterodimers inhibition interferes jurkat leukemia leukemic line lymphoblastic model oncogene oncogenes originally postulates proposed restored subsequently suggests supporting suppressing transcriptional underwent
Tagcloud (Difference) ?		10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4	activates arrest causes complexed contribute e2a expressing fusion heterodimers inhibition interferes jurkat leukemia leukemic line lymphoblastic model oncogene oncogenes originally postulates proposed restored subsequently suggests supporting suppressing transcriptional underwent
Tagcloud (Intersection) ?