TAL1 and LMO1

Number of citations of the paper that reports this interaction (PMID 8078932)
41

Data Source:
HPRD (in vivo)

		TAL1	LMO1
Gene Name		T-cell acute lymphocytic leukemia 1	LIM domain only 1 (rhombotin 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Transcription Factor Complex Lsd1/2 Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity E-box Binding	Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Locomotory Behavior Spinal Cord Association Neuron Differentiation Hemopoiesis Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Proliferation Erythrocyte Maturation Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Chromatin Assembly Or Disassembly Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Regulation Of Stem Cell Maintenance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Alcohol consumption ( 23743675) Fasting glucose-related traits (interaction with BMI) ( 22581228) Neuroblastoma ( 22941191 21124317)
Protein-Protein Interactions		23 interactors: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STUB1 TCF3 TCF4 ZHX1	38 interactors: ADAMTSL4 AES BCL11A BLZF1 CARD9 CDCA7L CDX4 CEP170P1 CEP44 ERBB2IP FAM154A FAM208B GABPB1 GATA3 GOLGA2 IKZF3 KANK2 KRT40 LDB1 LPXN LYL1 LZTS2 NHLH1 NUTM1 PHC2 PTPN3 RBBP8 REL SNTA1 SOX5 SPERT TAL1 TAL2 TCF4 TFIP11 TRIM27 ZBTB43 ZNF219
Entrez ID		6886	4004
HPRD ID		01753	01738
Ensembl ID		ENSG00000162367	ENSG00000166407
Uniprot IDs		P17542	P25800
PDB IDs		2YPA 2YPB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Embryo Development Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Binding Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Blood Coagulation Hemostasis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromosome Organization Negative Regulation Of Binding Regulation Of Hormone Metabolic Process Regulation Of Erythrocyte Differentiation Regulation Of Body Fluid Levels Biosynthetic Process Wound Healing Hemopoiesis Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Histone Modification Immune System Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Wnt Signaling Pathway Organ Development Positive Regulation Of Cellular Metabolic Process Interferon-gamma Secretion Multicellular Organismal Development Cellular Metabolic Process Anatomical Structure Development Developmental Process System Development Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Regulation Of Binding Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Definitive Hemopoiesis Embryo Development
Tagcloud ?		activates arrest causes complexed contribute e2a expressing fusion heterodimers inhibition interferes jurkat leukemia leukemic line lymphoblastic model oncogene oncogenes originally postulates proposed restored subsequently suggests supporting suppressing transcriptional underwent	bhlh collaborates collaboration construct demonstrating dispensable dysregulation elements exerts helix inappropriately interfere interstitial juxtaposed lastly lymphoblastic mesoderm misexpressed oncogenesis product recapitulating scl sil situation supporting tcl5 transactivation translocations whereby
Tagcloud (Difference) ?		activates arrest causes complexed contribute e2a expressing fusion heterodimers inhibition interferes jurkat leukemia leukemic line model oncogene oncogenes originally postulates proposed restored subsequently suggests suppressing transcriptional underwent	bhlh collaborates collaboration construct demonstrating dispensable dysregulation elements exerts helix inappropriately interfere interstitial juxtaposed lastly mesoderm misexpressed oncogenesis product recapitulating scl sil situation tcl5 transactivation translocations whereby
Tagcloud (Intersection) ?		lymphoblastic supporting