TAL1 and GATA2

Number of citations of the paper that reports this interaction (PMID 7568177)
45

Data Source:
BioGRID (two hybrid)

		TAL1	GATA2
Gene Name		T-cell acute lymphocytic leukemia 1	GATA binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Transcription Factor Complex Lsd1/2 Complex	Nucleoplasm Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity E-box Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Enhancer Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Locomotory Behavior Spinal Cord Association Neuron Differentiation Hemopoiesis Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Proliferation Erythrocyte Maturation Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Chromatin Assembly Or Disassembly Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Regulation Of Stem Cell Maintenance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Urogenital System Development Cell Fate Determination Embryonic Placenta Development Transcription, DNA-templated Phagocytosis Blood Coagulation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Somatic Stem Cell Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Definitive Hemopoiesis Semicircular Canal Development Negative Regulation Of Fat Cell Proliferation GABAergic Neuron Differentiation Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Forebrain Neuron Differentiation
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Eosinophil counts ( 19198610) White blood cell count ( 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		23 interactors: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STUB1 TCF3 TCF4 ZHX1	34 interactors: ADAMTSL4 AKT1 CEBPA EP300 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 LMO2 MAPK1 MDFI NOTCH2NL PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1
Entrez ID		6886	2624
HPRD ID		01753	00673
Ensembl ID		ENSG00000162367	ENSG00000179348
Uniprot IDs		P17542	P23769
PDB IDs		2YPA 2YPB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Embryo Development Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Binding Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Blood Coagulation Hemostasis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromosome Organization Negative Regulation Of Binding Regulation Of Hormone Metabolic Process Regulation Of Erythrocyte Differentiation Regulation Of Body Fluid Levels Biosynthetic Process Wound Healing Hemopoiesis Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Histone Modification Immune System Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Organ Development Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Hemopoiesis Immune System Development Embryo Development System Development Multicellular Organismal Development Biosynthetic Process Immune System Process Cellular Nitrogen Compound Metabolic Process Cardiovascular System Development Gland Development Regulation Of Metabolic Process Myeloid Cell Differentiation Regulation Of Binding Developmental Process Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Cell Differentiation Protein Localization To Nucleus Regulation Of Myeloid Cell Differentiation Nucleobase-containing Compound Metabolic Process Tissue Development
Tagcloud ?		activates arrest causes complexed contribute e2a expressing fusion heterodimers inhibition interferes jurkat leukemia leukemic line lymphoblastic model oncogene oncogenes originally postulates proposed restored subsequently suggests supporting suppressing transcriptional underwent	arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts erythropoiesis extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk
Tagcloud (Difference) ?		activates arrest causes complexed contribute e2a expressing fusion heterodimers inhibition interferes jurkat leukemia leukemic line lymphoblastic model oncogene oncogenes originally postulates proposed restored subsequently suggests supporting suppressing transcriptional underwent	arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts erythropoiesis extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk
Tagcloud (Intersection) ?