HLA-DPB1 and CD74

Number of citations of the paper that reports this interaction (PMID 16242130)
2

Data Source:
HPRD (in vivo)

		HLA-DPB1	CD74
Gene Name		major histocompatibility complex, class II, DP beta 1	CD74 molecule, major histocompatibility complex, class II invariant chain
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Intracellular Lysosomal Membrane Multivesicular Body Vacuole Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Peptide Antigen Binding	Beta-amyloid Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Binding Involved In Protein Folding Nitric-oxide Synthase Binding
	Biological Process	Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway	Activation Of MAPK Activity Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Protein Complex Assembly Intracellular Protein Transport Defense Response Signal Transduction Cell Proliferation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of B Cell Proliferation Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Chaperone Mediated Protein Folding Requiring Cofactor Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS		Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Hepatitis B ( 21750111 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) Nephropathy ( 21399633) Systemic sclerosis ( 21779181) Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		7 interactors: CD74 COPB1 HLA-DPA1 LZTS2 ROBO2 RTN4 TRIP6	14 interactors: APP CD1D CD44 CTSF CTSL HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA MIF
Entrez ID		3115	972
HPRD ID		00832	00825
Ensembl ID			ENSG00000019582
Uniprot IDs		I4EC15 P04440	P04233
PDB IDs		3LQZ	1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2
Enriched GO Terms of Interacting Partners?		Regulation Of Locomotion Neuron Recognition Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Macrophage Migration Inhibitory Factor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Migration Cell Recognition Negative Regulation Of Negative Chemotaxis Regulation Of Cell Motility Signal Transduction Regulation Of Chemotaxis Regulation Of Cellular Component Movement Apoptotic Process Involved In Luteolysis Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Axonogenesis Signaling Cellular Response To Organic Substance Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Negative Chemotaxis Negative Regulation Of Mature B Cell Apoptotic Process Cell Communication Regulation Of Behavior Regulation Of Protein Localization To Nucleus Axon Midline Choice Point Recognition Luteolysis Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Endoplasmic Reticulum Tubular Network Organization Cellular Response To Stimulus Olfactory Bulb Interneuron Development Antigen Processing And Presentation Telencephalon Development Spindle Midzone Assembly Positive Thymic T Cell Selection Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Negative Regulation Of B Cell Apoptotic Process Kidney Development Response To Organic Substance COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Immune Response Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Immune System Process Regulation Of Cell Activation Regulation Of T Cell Activation Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Immune System Process Defense Response Response To Interferon-gamma T Cell Costimulation Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly T Cell Receptor Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Antigen Receptor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Proliferation Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Cytokine Response To Organic Substance Response To Stress Response To Stimulus Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Organic Substance Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cell Proliferation
Tagcloud ?			actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?			actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?