HLA-DPB1

Gene Name		major histocompatibility complex, class II, DP beta 1
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Peptide Antigen Binding
	Biological Process	Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Hepatitis B ( 21750111 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) Nephropathy ( 21399633) Systemic sclerosis ( 21779181) Wegener's granulomatosis ( 23740775)
Protein-protein Interactions		7 interactors: CD74 COPB1 HLA-DPA1 LZTS2 ROBO2 RTN4 TRIP6
Entrez ID		3115
HPRD ID		00832
Ensembl ID
Uniprot IDs		I4EC15 P04440
PDB IDs		3LQZ
Enriched GO Terms of Interacting Partners?		Regulation Of Locomotion Neuron Recognition Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Macrophage Migration Inhibitory Factor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Migration Cell Recognition Negative Regulation Of Negative Chemotaxis Regulation Of Cell Motility Signal Transduction Regulation Of Chemotaxis Regulation Of Cellular Component Movement Apoptotic Process Involved In Luteolysis Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Axonogenesis Signaling Cellular Response To Organic Substance Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Negative Chemotaxis Negative Regulation Of Mature B Cell Apoptotic Process Cell Communication Regulation Of Behavior Regulation Of Protein Localization To Nucleus Axon Midline Choice Point Recognition Luteolysis Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Endoplasmic Reticulum Tubular Network Organization Cellular Response To Stimulus Olfactory Bulb Interneuron Development Antigen Processing And Presentation Telencephalon Development Spindle Midzone Assembly Positive Thymic T Cell Selection Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Negative Regulation Of B Cell Apoptotic Process Kidney Development Response To Organic Substance COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
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