HLA-DPB1 and HLA-DPA1

Number of citations of the paper that reports this interaction (PMID 8649448)
0

Data Source:
HPRD (in vivo)

		HLA-DPB1	HLA-DPA1
Gene Name		major histocompatibility complex, class II, DP beta 1	major histocompatibility complex, class II, DP alpha 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Peptide Antigen Binding	MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway	Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Hepatitis B ( 21750111 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) Nephropathy ( 21399633) Systemic sclerosis ( 21779181) Wegener's granulomatosis ( 23740775)	Hepatitis B ( 21750111) Hepatitis B (viral clearance) ( 22737229) Nephropathy ( 21399633) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		7 interactors: CD74 COPB1 HLA-DPA1 LZTS2 ROBO2 RTN4 TRIP6	3 interactors: CD4 CD74 HLA-DPB1
Entrez ID		3115	3113
HPRD ID		00832	00835
Ensembl ID			ENSG00000231389
Uniprot IDs		I4EC15 P04440	P20036
PDB IDs		3LQZ	3LQZ
Enriched GO Terms of Interacting Partners?		Regulation Of Locomotion Neuron Recognition Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Macrophage Migration Inhibitory Factor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Migration Cell Recognition Negative Regulation Of Negative Chemotaxis Regulation Of Cell Motility Signal Transduction Regulation Of Chemotaxis Regulation Of Cellular Component Movement Apoptotic Process Involved In Luteolysis Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Axonogenesis Signaling Cellular Response To Organic Substance Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Negative Chemotaxis Negative Regulation Of Mature B Cell Apoptotic Process Cell Communication Regulation Of Behavior Regulation Of Protein Localization To Nucleus Axon Midline Choice Point Recognition Luteolysis Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Endoplasmic Reticulum Tubular Network Organization Cellular Response To Stimulus Olfactory Bulb Interneuron Development Antigen Processing And Presentation Telencephalon Development Spindle Midzone Assembly Positive Thymic T Cell Selection Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Negative Regulation Of B Cell Apoptotic Process Kidney Development Response To Organic Substance COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation T Cell Selection Regulation Of Cytokine Production Regulation Of Cell Adhesion Positive Regulation Of Immune Response T Cell Costimulation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Antigen Receptor-mediated Signaling Pathway Induction By Virus Of Host Cell-cell Fusion Macrophage Migration Inhibitory Factor Signaling Pathway Protein Palmitoleylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Differentiation Immune Response Regulation Of Immune System Process Defense Response Regulation Of Peptidyl-tyrosine Phosphorylation Antigen Processing And Presentation Of Peptide Antigen Lymphocyte Differentiation T Cell Aggregation T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Lymphocyte Aggregation Antigen Processing And Presentation Leukocyte Aggregation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Mature B Cell Apoptotic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Cellular Amino Acid Metabolic Process Lymphocyte Activation
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