HDC and GZMA

Number of citations of the paper that reports this interaction (PMID 19059912)
11

Data Source:
BioGRID (enzymatic study)

		HDC	GZMA
Gene Name		histidine decarboxylase	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Immunological Synapse Extracellular Region Nucleus
	Molecular Function	Histidine Decarboxylase Activity Pyridoxal Phosphate Binding	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Histamine Biosynthetic Process Histidine Metabolic Process Histidine Catabolic Process Cellular Nitrogen Compound Metabolic Process Catecholamine Biosynthetic Process Small Molecule Metabolic Process	Apoptotic Process Immune Response Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		Histidine catabolism Metabolism of amino acids and derivatives
Drugs		Pyridoxal Phosphate L-Histidine
Diseases
GWAS
Protein-Protein Interactions		2 interactors: DTX2 GZMA	17 interactors: ACTG1 APEX1 GOLGA2 HDC HIST1H1A HIST2H2BE HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6
Entrez ID		3067	3001
HPRD ID		00817	00771
Ensembl ID		ENSG00000140287	ENSG00000145649
Uniprot IDs		B7ZM01 P19113	P12544
PDB IDs		4E1O	1HF1 1OP8 1ORF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Nuclease Activity Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Oxidoreductase Activity Cytolysis Negative Regulation Of DNA Binding Regulation Of Oxidoreductase Activity Regulation Of DNA Binding Negative Regulation Of DNA Metabolic Process Negative Regulation Of Binding Notch Signaling Pathway	DNA Conformation Change Cellular Hyperosmotic Salinity Response Organelle Organization Nucleosome Assembly Chromatin Assembly Protein Import Into Mitochondrial Outer Membrane Nucleosome Organization Cellular Macromolecular Complex Assembly Chromosome Organization Chromatin Assembly Or Disassembly Cellular Response To X-ray Protein-DNA Complex Assembly DNA Packaging Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Establishment Of Integrated Proviral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency DNA Recombination Execution Phase Of Apoptosis Telomere Maintenance Cellular Response To Salt Stress Chaperone-mediated Protein Complex Assembly DNA Ligation Protein Complex Assembly Double-strand Break Repair Via Nonhomologous End Joining Response To Unfolded Protein Hyperosmotic Response Mitotic Cell Cycle Double-strand Break Repair Protein Import Cellular Component Assembly Innate Immune Response V(D)J Recombination Cellular Response To Osmotic Stress Response To Stress Response To X-ray Response To Salt Stress Cellular Response To Stress Positive Regulation Of Cellular Biosynthetic Process Intracellular Protein Transmembrane Transport DNA Metabolic Process DNA Repair Positive Regulation Of Nuclease Activity Negative Regulation Of Apoptotic Signaling Pathway Sterol Regulatory Element Binding Protein Import Into Nucleus Cellular Response To Ionizing Radiation Protein Transmembrane Transport Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process
Tagcloud ?		aspirated bdf1 cavity connective constructs cotransfection decarboxylase differentiate disappeared e2 fluid gata histidine humoral incubation inoculated intraperitoneal luciferase mafk markedly mast mmcp p45 p815 peritoneal proliferate protease syngenic transactivation	ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing humoral ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated
Tagcloud (Difference) ?		aspirated bdf1 cavity connective constructs cotransfection decarboxylase differentiate disappeared e2 fluid gata histidine incubation inoculated intraperitoneal luciferase mafk markedly mast mmcp p45 p815 peritoneal proliferate protease syngenic transactivation	ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated
Tagcloud (Intersection) ?		humoral