GZMA and SET

Number of citations of the paper that reports this interaction (PMID 11555662)
26

Data Source:
HPRD (in vitro)

		GZMA	SET
Gene Name		granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	SET nuclear proto-oncogene
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity	DNA Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity Histone Binding
	Biological Process	Apoptotic Process Immune Response Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process	Mitotic Cell Cycle DNA Replication Nucleosome Assembly Nucleosome Disassembly Nucleocytoplasmic Transport Gene Expression Negative Regulation Of Histone Acetylation Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements Mitotic Prophase Condensation of Prophase Chromosomes HuR stabilizes mRNA Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		17 interactors: ACTG1 APEX1 GOLGA2 HDC HIST1H1A HIST2H2BE HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	51 interactors: ANP32A APEX1 APP CALM1 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 EP300 FAM111B FOS GZMA GZMK HDAC1 HIST1H2BA HIST1H3A HIST2H4A HIST3H3 HIST4H4 HMGB2 IRF1 JUNB KLF5 KMT2A MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PIK3CG PPP2CA PPP2R1B PRKAR1A PTMA RAC1 SDCBP SETBP1 SGOL1 TAF1A TERF1 TERF2 TERF2IP THAP7 TP53 TREX1 UCHL5
Entrez ID		3001	6418
HPRD ID		00771	09023
Ensembl ID		ENSG00000145649	ENSG00000119335
Uniprot IDs		P12544	Q01105 Q5VXV3
PDB IDs		1HF1 1OP8 1ORF	2E50
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Cellular Hyperosmotic Salinity Response Organelle Organization Nucleosome Assembly Chromatin Assembly Protein Import Into Mitochondrial Outer Membrane Nucleosome Organization Cellular Macromolecular Complex Assembly Chromosome Organization Chromatin Assembly Or Disassembly Cellular Response To X-ray Protein-DNA Complex Assembly DNA Packaging Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Establishment Of Integrated Proviral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency DNA Recombination Execution Phase Of Apoptosis Telomere Maintenance Cellular Response To Salt Stress Chaperone-mediated Protein Complex Assembly DNA Ligation Protein Complex Assembly Double-strand Break Repair Via Nonhomologous End Joining Response To Unfolded Protein Hyperosmotic Response Mitotic Cell Cycle Double-strand Break Repair Protein Import Cellular Component Assembly Innate Immune Response V(D)J Recombination Cellular Response To Osmotic Stress Response To Stress Response To X-ray Response To Salt Stress Cellular Response To Stress Positive Regulation Of Cellular Biosynthetic Process Intracellular Protein Transmembrane Transport DNA Metabolic Process DNA Repair Positive Regulation Of Nuclease Activity Negative Regulation Of Apoptotic Signaling Pathway Sterol Regulatory Element Binding Protein Import Into Nucleus Cellular Response To Ionizing Radiation Protein Transmembrane Transport Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Metabolic Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Telomere Maintenance Developmental Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Cycle Process Cellular Metabolic Process DNA Replication-dependent Nucleosome Assembly Cell Cycle Transcription, DNA-templated Organelle Organization Regulation Of Gene Expression, Epigenetic Blood Coagulation Positive Regulation Of Protein Metabolic Process Chromatin Assembly RNA Biosynthetic Process Cellular Component Assembly Hemostasis Chromatin Organization Negative Regulation Of Cell Cycle Anatomical Structure Development Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Negative Regulation Of Gene Expression
Tagcloud ?		ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing humoral ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated	already assessing cognition cognitive cogs computation correlating costs cps deterioration easy estimate exam global inasmuch mds meaningful mental mini minimum msd quite residents scale scales simple slightly straightforward substantially utility
Tagcloud (Difference) ?		ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing humoral ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated	already assessing cognition cognitive cogs computation correlating costs cps deterioration easy estimate exam global inasmuch mds meaningful mental mini minimum msd quite residents scale scales simple slightly straightforward substantially utility
Tagcloud (Intersection) ?