GZMA and HMGB2

Number of citations of the paper that reports this interaction (PMID 11909973)
17

Data Source:
BioGRID (pull down, enzymatic study)
HPRD (in vitro, in vivo)

		GZMA	HMGB2
Gene Name		granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	high mobility group box 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus	Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding Poly(A) RNA Binding RAGE Receptor Binding
	Biological Process	Apoptotic Process Immune Response Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process	Positive Regulation Of Endothelial Cell Proliferation DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity V(D)J Recombination Positive Regulation Of DNA Binding Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Chemotaxis DNA Ligation Involved In DNA Repair Cell Chemotaxis Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ACTG1 APEX1 GOLGA2 HDC HIST1H1A HIST2H2BE HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	20 interactors: APEX1 APP AR CHAF1A CREBBP CSNK1A1 GZMA GZMK HMGA1 NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SET TP53
Entrez ID		3001	3148
HPRD ID		00771	01229
Ensembl ID		ENSG00000145649
Uniprot IDs		P12544	P26583
PDB IDs		1HF1 1OP8 1ORF
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Cellular Hyperosmotic Salinity Response Organelle Organization Nucleosome Assembly Chromatin Assembly Protein Import Into Mitochondrial Outer Membrane Nucleosome Organization Cellular Macromolecular Complex Assembly Chromosome Organization Chromatin Assembly Or Disassembly Cellular Response To X-ray Protein-DNA Complex Assembly DNA Packaging Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Establishment Of Integrated Proviral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency DNA Recombination Execution Phase Of Apoptosis Telomere Maintenance Cellular Response To Salt Stress Chaperone-mediated Protein Complex Assembly DNA Ligation Protein Complex Assembly Double-strand Break Repair Via Nonhomologous End Joining Response To Unfolded Protein Hyperosmotic Response Mitotic Cell Cycle Double-strand Break Repair Protein Import Cellular Component Assembly Innate Immune Response V(D)J Recombination Cellular Response To Osmotic Stress Response To Stress Response To X-ray Response To Salt Stress Cellular Response To Stress Positive Regulation Of Cellular Biosynthetic Process Intracellular Protein Transmembrane Transport DNA Metabolic Process DNA Repair Positive Regulation Of Nuclease Activity Negative Regulation Of Apoptotic Signaling Pathway Sterol Regulatory Element Binding Protein Import Into Nucleus Cellular Response To Ionizing Radiation Protein Transmembrane Transport Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Chromosome Organization Macromolecule Biosynthetic Process Regulation Of Metabolic Process Organ Development Chromatin Organization Cellular Metabolic Process Developmental Process Lymphocyte Differentiation B Cell Differentiation Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Assembly Leukocyte Differentiation T Cell Differentiation Chromatin Assembly Or Disassembly B Cell Activation Positive Regulation Of Cell Aging Transcription Initiation From RNA Polymerase II Promoter B Cell Lineage Commitment Cell Activation Multicellular Organismal Development DNA Metabolic Process DNA Packaging Lymphocyte Activation Intracellular Receptor Signaling Pathway
Tagcloud ?		ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing humoral ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated	advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified
Tagcloud (Difference) ?		ark boosting bronchitis calt cd3 cd44 chickens compartment compartments contraction cytotoxic effector granzyme halt homing humoral ibv lesser lymphocyte mirrored mucosal ocular ocularly perforin poultry presumably shifted spleen vaccinated	advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified
Tagcloud (Intersection) ?