GZMK and NPLOC4

Number of citations of the paper that reports this interaction (PMID 20876349)
7

Data Source:
BioGRID (enzymatic study)

		GZMK	NPLOC4
Gene Name		granzyme K (granzyme 3; tryptase II)	nuclear protein localization 4 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Nucleus Endoplasmic Reticulum Cytosol Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Protein Binding Zinc Ion Binding
	Biological Process	Proteolysis	Golgi Organization ER-associated Ubiquitin-dependent Protein Catabolic Process Membrane Fusion
Pathways
Drugs
Diseases
GWAS			Eye color traits ( 20463881)
Protein-Protein Interactions		12 interactors: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TUBB3 UFD1L VCP	6 interactors: GZMK NEDD8 RAF1 UBC UFD1L VCP
Entrez ID		3003	55666
HPRD ID		02872	06975
Ensembl ID			ENSG00000182446
Uniprot IDs		P49863	Q8TAT6
PDB IDs		1MZA 1MZD
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Catabolic Process DNA Metabolic Process DNA Repair DNA Replication DNA Ligation Involved In DNA Repair Nucleotide-excision Repair DNA-dependent DNA Replication DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus DNA Catabolic Process Double-strand Break Repair V(D)J Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process DNA Recombination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Organelle Organization Cell Cycle Mitotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Base-excision Repair DNA Ligation Involved In DNA Recombination Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Stress DNA Catabolic Process, Endonucleolytic Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Polynucleotide 3' Dephosphorylation Chromosome Organization Protein Complex Assembly Aromatic Compound Catabolic Process DNA Biosynthetic Process Cellular Component Assembly Nucleosome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Chromatin Assembly Proteolysis Involved In Cellular Protein Catabolic Process Nucleosome Organization Cellular Protein Catabolic Process Base-excision Repair, DNA Ligation Retrograde Protein Transport, ER To Cytosol Chromatin Assembly Or Disassembly Regulation Of Protein Deubiquitination Lagging Strand Elongation	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Death-inducing Signaling Complex Assembly Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Catabolic Process Cellular Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Neurotrophin TRK Receptor Signaling Pathway Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Catabolic Process Apoptotic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Programmed Cell Death Regulation Of Protein Deubiquitination Protein Processing Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Death Death Response To Organic Substance Protein Hexamerization Response To Abiotic Stimulus
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