GZMK and TUBB3

Number of citations of the paper that reports this interaction (PMID 19059912)
11

Data Source:
BioGRID (enzymatic study)

		GZMK	TUBB3
Gene Name		granzyme K (granzyme 3; tryptase II)	tubulin, beta 3 class III
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Nucleus Cytoplasm Microtubule Axon Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding
	Biological Process	Proteolysis	Protein Folding Microtubule-based Process Mitotic Nuclear Division Axon Guidance Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Transmembrane Transport
Pathways			Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Epothilone D Epothilone B Ixabepilone
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TUBB3 UFD1L VCP	27 interactors: ANXA7 ARHGEF7 CAMSAP3 CDKN1A DDX39B EEF1G GABARAP GZMK HEXDC INSM1 KHDRBS1 LAPTM4A LIG1 MRPL28 MTCL1 PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE
Entrez ID		3003	10381
HPRD ID		02872	04044
Ensembl ID			ENSG00000258947
Uniprot IDs		P49863	A8K854 Q13509 Q53G92
PDB IDs		1MZA 1MZD
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Catabolic Process DNA Metabolic Process DNA Repair DNA Replication DNA Ligation Involved In DNA Repair Nucleotide-excision Repair DNA-dependent DNA Replication DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus DNA Catabolic Process Double-strand Break Repair V(D)J Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process DNA Recombination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Organelle Organization Cell Cycle Mitotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Base-excision Repair DNA Ligation Involved In DNA Recombination Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Stress DNA Catabolic Process, Endonucleolytic Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Polynucleotide 3' Dephosphorylation Chromosome Organization Protein Complex Assembly Aromatic Compound Catabolic Process DNA Biosynthetic Process Cellular Component Assembly Nucleosome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Chromatin Assembly Proteolysis Involved In Cellular Protein Catabolic Process Nucleosome Organization Cellular Protein Catabolic Process Base-excision Repair, DNA Ligation Retrograde Protein Transport, ER To Cytosol Chromatin Assembly Or Disassembly Regulation Of Protein Deubiquitination Lagging Strand Elongation	Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Mitotic Cell Cycle Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Cell Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Division Cell Cycle Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Response To Toxic Substance Negative Regulation Of Chromosome Segregation Cell Division Cytoskeleton Organization Microtubule Bundle Formation Positive Regulation Of Microtubule Motor Activity Fetal Process Involved In Parturition Columnar/cuboidal Epithelial Cell Development Regulation Of DNA Biosynthetic Process Microtubule-based Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Epithelial Cell Development Regulation Of Cell Morphogenesis Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Spliceosomal Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?			actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tyms vegfr2
Tagcloud (Difference) ?			actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tyms vegfr2
Tagcloud (Intersection) ?