GZMK and HMGB2

Number of citations of the paper that reports this interaction (PMID 17008916)
13

Data Source:
BioGRID (enzymatic study)

		GZMK	HMGB2
Gene Name		granzyme K (granzyme 3; tryptase II)	high mobility group box 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding Poly(A) RNA Binding RAGE Receptor Binding
	Biological Process	Proteolysis	Positive Regulation Of Endothelial Cell Proliferation DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity V(D)J Recombination Positive Regulation Of DNA Binding Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Chemotaxis DNA Ligation Involved In DNA Repair Cell Chemotaxis Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TUBB3 UFD1L VCP	20 interactors: APEX1 APP AR CHAF1A CREBBP CSNK1A1 GZMA GZMK HMGA1 NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SET TP53
Entrez ID		3003	3148
HPRD ID		02872	01229
Ensembl ID
Uniprot IDs		P49863	P26583
PDB IDs		1MZA 1MZD
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Catabolic Process DNA Metabolic Process DNA Repair DNA Replication DNA Ligation Involved In DNA Repair Nucleotide-excision Repair DNA-dependent DNA Replication DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus DNA Catabolic Process Double-strand Break Repair V(D)J Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process DNA Recombination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Organelle Organization Cell Cycle Mitotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Base-excision Repair DNA Ligation Involved In DNA Recombination Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Stress DNA Catabolic Process, Endonucleolytic Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Polynucleotide 3' Dephosphorylation Chromosome Organization Protein Complex Assembly Aromatic Compound Catabolic Process DNA Biosynthetic Process Cellular Component Assembly Nucleosome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Chromatin Assembly Proteolysis Involved In Cellular Protein Catabolic Process Nucleosome Organization Cellular Protein Catabolic Process Base-excision Repair, DNA Ligation Retrograde Protein Transport, ER To Cytosol Chromatin Assembly Or Disassembly Regulation Of Protein Deubiquitination Lagging Strand Elongation	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Chromosome Organization Macromolecule Biosynthetic Process Regulation Of Metabolic Process Organ Development Chromatin Organization Cellular Metabolic Process Developmental Process Lymphocyte Differentiation B Cell Differentiation Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Assembly Leukocyte Differentiation T Cell Differentiation Chromatin Assembly Or Disassembly B Cell Activation Positive Regulation Of Cell Aging Transcription Initiation From RNA Polymerase II Promoter B Cell Lineage Commitment Cell Activation Multicellular Organismal Development DNA Metabolic Process DNA Packaging Lymphocyte Activation Intracellular Receptor Signaling Pathway
Tagcloud ?			advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified
Tagcloud (Difference) ?			advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified
Tagcloud (Intersection) ?