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GTF2H1 and ACTN1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
GTF2H1
ACTN1
Gene Name
general transcription factor IIH, polypeptide 1, 62kDa
actinin, alpha 1
Image
Gene Ontology Annotations
Cellular Component
Core TFIIH Complex
Nucleoplasm
Holo TFIIH Complex
Stress Fiber
Ruffle
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Fascia Adherens
Focal Adhesion
Z Disc
Cortical Actin Cytoskeleton
Platelet Alpha Granule Lumen
Pseudopodium
Cell Projection
Dendritic Spine
Extracellular Vesicular Exosome
Molecular Function
Protein Kinase Activity
Protein Binding
DNA-dependent ATPase Activity
RNA Polymerase II Carboxy-terminal Domain Kinase Activity
Double-stranded RNA Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Vinculin Binding
Protein Domain Specific Binding
Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Ion Channel Binding
Actin Filament Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Nucleotide-excision Repair, DNA Damage Removal
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Phosphorylation
Gene Expression
Viral Process
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Viral Transcription
Platelet Degranulation
Blood Coagulation
Platelet Activation
Extracellular Matrix Organization
Cell Junction Assembly
Regulation Of Apoptotic Process
Focal Adhesion Assembly
Actin Filament Bundle Assembly
Negative Regulation Of Cellular Component Movement
Actin Crosslink Formation
Regulation Of Nucleic Acid-templated Transcription
Pathways
RNA Polymerase II Promoter Escape
Formation of HIV-1 elongation complex containing HIV-1 Tat
Nucleotide Excision Repair
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HIV Infection
Formation of the Early Elongation Complex
Tat-mediated elongation of the HIV-1 transcript
Formation of transcription-coupled NER (TC-NER) repair complex
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
Dual incision reaction in TC-NER
NoRC negatively regulates rRNA expression
HIV Transcription Initiation
HIV Life Cycle
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II HIV Promoter Escape
HIV Transcription Elongation
Dual incision reaction in GG-NER
mRNA Capping
RNA Polymerase I Transcription
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Late Phase of HIV Life Cycle
Formation of RNA Pol II elongation complex
Global Genomic NER (GG-NER)
RNA Polymerase II Transcription Initiation And Promoter Clearance
Transcription-coupled NER (TC-NER)
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of incision complex in GG-NER
RNA Polymerase II Transcription Initiation
Transcription of the HIV genome
RNA Polymerase II Transcription Elongation
Cell junction organization
Syndecan interactions
Response to elevated platelet cytosolic Ca2+
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Nephrin interactions
Platelet degranulation
Non-integrin membrane-ECM interactions
Platelet activation, signaling and aggregation
Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Amyloid A Levels (
21124955
)
Pancreatic cancer (
23180869
)
Prostate cancer (
23535732
)
Smoking behavior (
19247474
)
Protein-Protein Interactions
42 interactors:
ACTN1
AR
ATF7IP
BRPF1
CCNH
CCSER2
CDK7
CTD
E2F1
ERCC2
ERCC3
ERCC4
ERCC5
ESR1
FUBP1
GTF2E1
GTF2E2
GTF2H2
GTF2H3
HNF4A
HNRNPU
HOXC11
JDP2
KIF13A
KPNA3
MCM2
MMS19
PIK3R1
PLCG1
POU2AF1
PSMC2
RAD23A
REEP5
RXRB
TNIP1
TP53
TRIOBP
TXNRD2
USHBP1
XPA
XPC
ZSCAN1
70 interactors:
ACTN3
ADORA2A
APC
ATXN2
ATXN7
CACNA1A
CAMK2A
CDK5
CDK5R1
CDK5R2
CLIC5
COIL
COL17A1
CSRP1
CSRP3
CTNNA1
EPM2AIP1
ERBB2IP
FBP1
FXN
GFI1B
GIPC1
GIT2
GRIA4
GRIN2A
GTF2H1
ITGB1
KAT2B
KCTD6
KPNA2
LPP
MAGEA11
MAP2
MAP3K1
MED14
MICALL2
MYOT
MYOZ1
MYOZ2
MYOZ3
NEBL
NR1H3
NUMBL
OAS1
PALLD
PDHX
PDLIM1
PDLIM5
PIAS4
PKD1
PKN1
PLD2
PSEN1
PSMA1
PTK2
PTPN1
PTPN6
PYGB
RAVER1
RPS27
SLC2A4
SORBS2
SPERT
SRC
SSX2IP
TES
TTN
VCL
XRCC4
ZYX
Entrez ID
2965
87
HPRD ID
01807
00020
Ensembl ID
ENSG00000110768
ENSG00000072110
Uniprot IDs
P32780
P12814
PDB IDs
1PFJ
2DII
2RNR
2EYI
2EYN
Enriched GO Terms of Interacting Partners
?
Nucleotide-excision Repair, DNA Damage Removal
Nucleotide-excision Repair
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Transcription-coupled Nucleotide-excision Repair
Viral Process
Cellular Response To DNA Damage Stimulus
Transcription From RNA Polymerase II Promoter
DNA Catabolic Process
Transcription Elongation From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription, DNA-templated
Positive Regulation Of Gene Expression
Response To UV
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA-templated Transcription, Elongation
Positive Regulation Of Cellular Biosynthetic Process
RNA Biosynthetic Process
Termination Of RNA Polymerase I Transcription
Gene Expression
Transcription Elongation From RNA Polymerase I Promoter
Nitrogen Compound Metabolic Process
DNA Repair
Transcription Initiation From RNA Polymerase I Promoter
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
7-methylguanosine MRNA Capping
Transcription From RNA Polymerase I Promoter
7-methylguanosine RNA Capping
Positive Regulation Of Viral Process
DNA Metabolic Process
RNA Metabolic Process
Cellular Response To Stress
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Viral Transcription
Regulation Of Viral Process
Nucleotide-excision Repair, DNA Incision
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Regulation Of Viral Transcription
Response To Stress
Cytoskeleton Organization
Cell Adhesion
Cellular Component Assembly
Organelle Organization
Cell Development
Regulation Of Protein Kinase Activity
Actin Filament-based Process
Regulation Of Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Actin Cytoskeleton Organization
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Metabolic Process
Cell-substrate Adhesion
Anatomical Structure Morphogenesis
Neurogenesis
Regulation Of Phosphorus Metabolic Process
Cell Differentiation
Generation Of Neurons
Cell Morphogenesis
Regulation Of Protein Phosphorylation
Response To Stress
Actomyosin Structure Organization
Neuron Development
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Catalytic Activity
Central Nervous System Development
Positive Regulation Of Transferase Activity
Regulation Of Signaling
Response To Stimulus
Response To Wounding
Regulation Of Phosphorylation
Cell-cell Junction Organization
Regulation Of Cell Projection Organization
Nervous System Development
Anatomical Structure Formation Involved In Morphogenesis
Single Organismal Cell-cell Adhesion
Adherens Junction Organization
Neuron Projection Development
Neuron Differentiation
Anatomical Structure Development
Blood Coagulation
Cell Surface Receptor Signaling Pathway
Cell Projection Organization
Hemostasis
Cell-matrix Adhesion
Apical Junction Assembly
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Signal Transduction
Regulation Of Cell Death
Regulation Of Neuron Projection Development
Tagcloud
?
b5
bcat1
carbamoyl
ctnnd1
egfr1
eph
filamin
flna
genego
i2d
interactors
interologous
metadherin
mtdh
nucleolin
pathwaycommons
plec
plectin
pycard
pyd
rpkm
s100a2
serpinb5
signalings
stratifin
subpathway
sum149
sum190
tfrc
Tagcloud (Difference)
?
b5
bcat1
carbamoyl
ctnnd1
egfr1
eph
filamin
flna
genego
i2d
interactors
interologous
metadherin
mtdh
nucleolin
pathwaycommons
plec
plectin
pycard
pyd
rpkm
s100a2
serpinb5
signalings
stratifin
subpathway
sum149
sum190
tfrc
Tagcloud (Intersection)
?