GTF2H1 and KIF13A

Number of citations of the paper that reports this interaction (PMID 10777215)
12

Data Source:
HPRD (in vivo, in vitro)

		GTF2H1	KIF13A
Gene Name		general transcription factor IIH, polypeptide 1, 62kDa	kinesin family member 13A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex	Golgi Membrane Centrosome Kinesin Complex Microtubule Endosome Membrane Midbody Trans-Golgi Network Membrane
	Molecular Function	Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Cytokinesis Intracellular Protein Transport Microtubule-based Movement Metabolic Process Endosome To Lysosome Transport Melanosome Organization Cargo Loading Into Vesicle Golgi To Plasma Membrane Protein Transport Plus-end-directed Vesicle Transport Along Microtubule
Pathways		RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Amyloid A Levels ( 21124955) Pancreatic cancer ( 23180869)	Height ( 18391951) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		42 interactors: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 CTD E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 USHBP1 XPA XPC ZSCAN1	7 interactors: AP1B1 AP1G1 AP1M1 ATF7IP GTF2H1 PIH1D3 PPP1CA
Entrez ID		2965	63971
HPRD ID		01807	09256
Ensembl ID		ENSG00000110768	ENSG00000137177
Uniprot IDs		P32780	Q9H1H9
PDB IDs		1PFJ 2DII 2RNR
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Damage Removal Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription-coupled Nucleotide-excision Repair Viral Process Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter DNA Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Response To UV Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Gene Expression Transcription Elongation From RNA Polymerase I Promoter Nitrogen Compound Metabolic Process DNA Repair Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Viral Process DNA Metabolic Process RNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Viral Process Nucleotide-excision Repair, DNA Incision Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Response To Stress	Regulation Of Defense Response To Virus By Virus Viral Process Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Pigment Granule Maturation Endosome To Melanosome Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Pigment Accumulation Melanosome Organization Pigment Granule Organization Antigen Processing And Presentation Of Peptide Antigen Golgi Vesicle Transport Antigen Processing And Presentation Cellular Pigmentation Developmental Pigmentation Pigmentation Positive Regulation Of Natural Killer Cell Degranulation Golgi To Lysosome Transport Membrane Organization Endosomal Transport Vesicle Organization Regulation Of Gene Expression, Epigenetic Intracellular Protein Transport Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Golgi To Vacuole Transport Regulation Of Glycogen Catabolic Process Axonemal Dynein Complex Assembly Regulation Of Immune System Process Cellular Protein Localization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Nucleotide-excision Repair, DNA Damage Removal Protein Transport Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Triglyceride Catabolic Process Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of DNA-templated Transcription, Initiation Entrainment Of Circadian Clock By Photoperiod Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Intracellular Transport Positive Regulation Of Natural Killer Cell Activation Termination Of RNA Polymerase I Transcription Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Transcription Elongation From RNA Polymerase I Promoter
Tagcloud ?			adaptin adaptor ap associates blockade cargo cargoes contained directed end kifs kinesin m6pr mannnose microtubule mislocalization motor phosphate plus remains respective subunit superfamily targets tgn transport transports unclear vesicles
Tagcloud (Difference) ?			adaptin adaptor ap associates blockade cargo cargoes contained directed end kifs kinesin m6pr mannnose microtubule mislocalization motor phosphate plus remains respective subunit superfamily targets tgn transport transports unclear vesicles
Tagcloud (Intersection) ?