GTF2H1 and REEP5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GTF2H1	REEP5
Gene Name		general transcription factor IIH, polypeptide 1, 62kDa	receptor accessory protein 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex	Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity	Molecular_function Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Biological_process
Pathways		RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Amyloid A Levels ( 21124955) Pancreatic cancer ( 23180869)	Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		42 interactors: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 CTD E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 USHBP1 XPA XPC ZSCAN1	7 interactors: ARFGAP1 GTF2H1 NUDT3 RAB5B RABAC1 RGS2 VKORC1
Entrez ID		2965	7905
HPRD ID		01807	15918
Ensembl ID		ENSG00000110768	ENSG00000129625
Uniprot IDs		P32780	B7Z681 Q00765
PDB IDs		1PFJ 2DII 2RNR
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Damage Removal Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription-coupled Nucleotide-excision Repair Viral Process Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter DNA Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Response To UV Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Gene Expression Transcription Elongation From RNA Polymerase I Promoter Nitrogen Compound Metabolic Process DNA Repair Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Viral Process DNA Metabolic Process RNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Viral Process Nucleotide-excision Repair, DNA Incision Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Response To Stress	Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Adrenergic Receptor Signaling Pathway Vitamin K Metabolic Process Positive Regulation Of Cardiac Muscle Contraction Regulation Of Protein Phosphorylation Negative Regulation Of CAMP-mediated Signaling Plasma Membrane To Endosome Transport Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorylation COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Microtubule Polymerization Peptidyl-glutamic Acid Carboxylation Relaxation Of Cardiac Muscle Golgi Vesicle Budding Negative Regulation Of Smooth Muscle Contraction Regulation Of Phosphorus Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Aromatic Compound Catabolic Process Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Vesicle Targeting, To, From Or Within Golgi Endosome Organization Regulation Of Cardiac Muscle Hypertrophy 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter Vasodilation 7-methylguanosine RNA Capping Regulation Of Cellular Protein Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To ER Quinone Metabolic Process Drug Metabolic Process Transcription-coupled Nucleotide-excision Repair Localization Within Membrane Vesicle Targeting
Tagcloud ?			5q22 adjusted apc caner chose cnv copy discovering exon9 fluorophores gastric integer interrogate intron8 losses obtain original platform probe probes searched sought srp19 surrounding taqman transformed variation volunteers yielded
Tagcloud (Difference) ?			5q22 adjusted apc caner chose cnv copy discovering exon9 fluorophores gastric integer interrogate intron8 losses obtain original platform probe probes searched sought srp19 surrounding taqman transformed variation volunteers yielded
Tagcloud (Intersection) ?