MSH6 and SMC1A

Number of citations of the paper that reports this interaction (PMID 14657349)
58

Data Source:
BioGRID (pull down)

		MSH6	SMC1A
Gene Name		mutS homolog 6	structural maintenance of chromosomes 1A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nuclear Chromatin Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane MutSalpha Complex Intracellular Membrane-bounded Organelle	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Cohesin Core Heterodimer Meiotic Cohesin Complex
	Molecular Function	Magnesium Ion Binding Four-way Junction DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity ATPase Activity Mismatched DNA Binding Guanine/thymine Mispair Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Methylated Histone Binding Protein Homodimerization Activity ADP Binding	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Meiotic Mismatch Repair DNA Repair Mismatch Repair Reciprocal Meiotic Recombination Determination Of Adult Lifespan Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle MRNA Splicing, Via Spliceosome DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division RNA Splicing Response To Radiation Gene Expression Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Signal Transduction In Response To DNA Damage Cell Division
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	Establishment of Sister Chromatid Cohesion Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin mRNA Splicing - Major Pathway Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BARD1 BRCA1 CHAF1A CREBBP CSNK2A1 EP300 HUS1 MSH2 MUTYH PCNA RAD1 RAD9A SMC1A	16 interactors: ATM BLM BRCA1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3
Entrez ID		2956	8243
HPRD ID		07202	02077
Ensembl ID		ENSG00000116062	ENSG00000072501
Uniprot IDs		B4DF41 B4E3I4 F5H2F9 P52701 Q3SWU9	Q14683 Q68EN4
PDB IDs		2GFU 2O8B 2O8C 2O8D 2O8E 2O8F
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress Cell Cycle Cell Cycle Process DNA Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Response To Ionizing Radiation DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Response To Abiotic Stimulus Mitotic Cell Cycle Process Mitotic Cell Cycle Cellular Response To Stimulus Response To Radiation Negative Regulation Of Mitotic Cell Cycle Postreplication Repair N-terminal Peptidyl-lysine Acetylation Response To Stimulus Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Mismatch Repair Regulation Of Cell Cycle Process Cellular Response To Ionizing Radiation DNA Recombination Protein K6-linked Ubiquitination Chromosome Organization Negative Regulation Of Cell Division Intra-S DNA Damage Checkpoint Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process N-terminal Protein Amino Acid Acetylation Negative Regulation Of DNA Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of DNA Replication DNA Catabolic Process Cellular Response To Radiation Negative Regulation Of Meiotic Nuclear Division	Cell Cycle Process Cell Cycle Mitotic Cell Cycle DNA Recombination Mitotic Cell Cycle Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair Double-strand Break Repair Organelle Organization Cellular Response To Stress Meiotic Cell Cycle DNA Strand Elongation Involved In DNA Replication Chromosome Organization DNA Strand Elongation DNA-dependent DNA Replication DNA Replication DNA Damage Checkpoint Meiotic Nuclear Division Telomere Maintenance Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Meiosis I DNA Replication Initiation Response To Stress Meiotic Mismatch Repair Nitrogen Compound Metabolic Process G2 DNA Damage Checkpoint Response To Ionizing Radiation Reciprocal Meiotic Recombination Mitotic Cell Cycle Checkpoint Positive Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway Response To Radiation Regulation Of DNA Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation DNA Duplex Unwinding DNA Geometric Change
Tagcloud ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected
Tagcloud (Difference) ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected
Tagcloud (Intersection) ?		exome