GRIK2 and TRIM25

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GRIK2	TRIM25
Gene Name		glutamate receptor, ionotropic, kainate 2	tripartite motif containing 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Cell Junction Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Poly(A) RNA Binding
	Biological Process	Behavioral Fear Response Transport Cellular Calcium Ion Homeostasis Intracellular Protein Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Neuronal Action Potential Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential	Viral Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Activation of Na-permeable Kainate Receptors Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs		L-Glutamic Acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Domoic Acid Quisqualate 2s,4r-4-Methylglutamate
Diseases
GWAS		Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) plasma levels ( 23362303) Renal function-related traits (eGRFcrea) ( 22797727)	Height ( 18391951)
Protein-Protein Interactions		18 interactors: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25	27 interactors: AMFR DDX58 ERCC2 ESR1 GATA1 GRIK2 MEIS2 OTUB2 PITX2 RARRES3 RBCK1 RNF31 SFN STK38 TFG TRAF6 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L6 UBE2N USP15 USP39 ZNF24
Entrez ID		2898	7706
HPRD ID		00692	02711
Ensembl ID		ENSG00000164418	ENSG00000121060
Uniprot IDs		A8K0H7 F8WEZ8 Q13002 Q8IY40	Q14258
PDB IDs		3QXM
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Signaling Cell Communication Receptor Localization To Synapse Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Nucleotide Phosphorylation Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Protein Localization Protein Localization Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Differentiation Signal Transduction Neurogenesis Nervous System Development Membrane Organization Response To External Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Generation Of Neurons Establishment Or Maintenance Of Cell Polarity Maintenance Of Apical/basal Cell Polarity Cell Junction Assembly Negative Regulation Of Signaling Cellular Response To Stimulus Cell-cell Junction Organization Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Localization Cell Development Regulation Of Postsynaptic Membrane Potential Response To Stimulus Adherens Junction Organization Maintenance Of Cell Polarity Positive Regulation Of Cellular Metabolic Process System Development Regulation Of Membrane Potential Wnt Signaling Pathway Neuron Development Positive Regulation Of Metabolic Process Regulation Of Synaptic Transmission Regulation Of Cellular Process Long Term Synaptic Depression	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Organic Substance Activation Of Innate Immune Response Proteolysis Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Immune System Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Signaling Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Communication Response To Stimulus Cellular Response To Stimulus Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cellular Metabolic Process Negative Regulation Of Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance
Tagcloud ?		ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Difference) ?		ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Intersection) ?