GRIK2 and GRIK4

Number of citations of the paper that reports this interaction (PMID 12954862)
33

Data Source:
HPRD (in vivo)

		GRIK2	GRIK4
Gene Name		glutamate receptor, ionotropic, kainate 2	glutamate receptor, ionotropic, kainate 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Cell Junction Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane
	Molecular Function	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity
	Biological Process	Behavioral Fear Response Transport Cellular Calcium Ion Homeostasis Intracellular Protein Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Neuronal Action Potential Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Response To Corticosteroid Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Activation of Na-permeable Kainate Receptors Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Domoic Acid Quisqualate 2s,4r-4-Methylglutamate	L-Glutamic Acid
Diseases
GWAS		Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) plasma levels ( 23362303) Renal function-related traits (eGRFcrea) ( 22797727)	Attention deficit hyperactivity disorder ( 23728934) Cognitive performance ( 20125193)
Protein-Protein Interactions		18 interactors: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25	2 interactors: GRIK2 RAB5A
Entrez ID		2898	2900
HPRD ID		00692	02613
Ensembl ID		ENSG00000164418	ENSG00000149403
Uniprot IDs		A8K0H7 F8WEZ8 Q13002 Q8IY40	Q16099
PDB IDs		3QXM
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Signaling Cell Communication Receptor Localization To Synapse Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Nucleotide Phosphorylation Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Protein Localization Protein Localization Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Differentiation Signal Transduction Neurogenesis Nervous System Development Membrane Organization Response To External Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Generation Of Neurons Establishment Or Maintenance Of Cell Polarity Maintenance Of Apical/basal Cell Polarity Cell Junction Assembly Negative Regulation Of Signaling Cellular Response To Stimulus Cell-cell Junction Organization Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Localization Cell Development Regulation Of Postsynaptic Membrane Potential Response To Stimulus Adherens Junction Organization Maintenance Of Cell Polarity Positive Regulation Of Cellular Metabolic Process System Development Regulation Of Membrane Potential Wnt Signaling Pathway Neuron Development Positive Regulation Of Metabolic Process Regulation Of Synaptic Transmission Regulation Of Cellular Process Long Term Synaptic Depression	Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Transport Regulation Of Neuronal Synaptic Plasticity Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission Regulation Of Endosome Size Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Regulation Of Secretion Protein Retention In ER Lumen Regulation Of Short-term Neuronal Synaptic Plasticity Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Intracellular Protein Transport Early Endosome To Late Endosome Transport Regulation Of Cellular Localization Positive Regulation Of Smooth Muscle Cell Migration Neuronal Action Potential Membrane Hyperpolarization Behavioral Fear Response Regulation Of Vesicle Fusion Synaptic Vesicle Recycling Fear Response Cellular Protein Localization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Migration Protein Transport Receptor Internalization Establishment Of Protein Localization Regulation Of Filopodium Assembly Receptor Clustering Intracellular Transport Transmission Of Nerve Impulse Neuron Apoptotic Process Positive Regulation Of Smooth Muscle Cell Proliferation Rab Protein Signal Transduction Positive Regulation Of Neuron Apoptotic Process Glutamate Receptor Signaling Pathway Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic
Tagcloud ?		ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive	500x abl actionable alk amplifications asxl1 copy correctly coverage deep deletions duplications eml4 formalin gains guide insertions losses mixing mll oncoplex paraffin pik3r1 rearrangements ros1 sgcz underdeveloped uw validate
Tagcloud (Difference) ?		ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive	500x abl actionable alk amplifications asxl1 copy correctly coverage deep deletions duplications eml4 formalin gains guide insertions losses mixing mll oncoplex paraffin pik3r1 rearrangements ros1 sgcz underdeveloped uw validate
Tagcloud (Intersection) ?