GRIK2 and CALCOCO1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GRIK2	CALCOCO1
Gene Name		glutamate receptor, ionotropic, kainate 2	calcium binding and coiled-coil domain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Cell Junction Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane	Nuclear Chromatin Nucleus Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity	Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Armadillo Repeat Domain Binding
	Biological Process	Behavioral Fear Response Transport Cellular Calcium Ion Homeostasis Intracellular Protein Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Neuronal Action Potential Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential	Transcription, DNA-templated Signal Transduction Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Activation of Na-permeable Kainate Receptors Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Domoic Acid Quisqualate 2s,4r-4-Methylglutamate
Diseases
GWAS		Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) plasma levels ( 23362303) Renal function-related traits (eGRFcrea) ( 22797727)	Panic disorder ( 19165232)
Protein-Protein Interactions		18 interactors: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25	26 interactors: APP APTX CEP19 CREBBP CRYBA2 CTNNBL1 CWF19L2 CYTH3 DUSP13 EP300 FAM161A FOSL1 GABARAPL2 GRIK2 HIST1H3A HIST1H4A IPP ISOC1 KRT15 MAPK1 NDC80 NEDD4 PCBD1 SH3GL3 TBC1D15 TBC1D17
Entrez ID		2898	57658
HPRD ID		00692	13868
Ensembl ID		ENSG00000164418	ENSG00000012822
Uniprot IDs		A8K0H7 F8WEZ8 Q13002 Q8IY40	Q9P1Z2
PDB IDs		3QXM
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Signaling Cell Communication Receptor Localization To Synapse Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Nucleotide Phosphorylation Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Protein Localization Protein Localization Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Differentiation Signal Transduction Neurogenesis Nervous System Development Membrane Organization Response To External Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Generation Of Neurons Establishment Or Maintenance Of Cell Polarity Maintenance Of Apical/basal Cell Polarity Cell Junction Assembly Negative Regulation Of Signaling Cellular Response To Stimulus Cell-cell Junction Organization Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Localization Cell Development Regulation Of Postsynaptic Membrane Potential Response To Stimulus Adherens Junction Organization Maintenance Of Cell Polarity Positive Regulation Of Cellular Metabolic Process System Development Regulation Of Membrane Potential Wnt Signaling Pathway Neuron Development Positive Regulation Of Metabolic Process Regulation Of Synaptic Transmission Regulation Of Cellular Process Long Term Synaptic Depression	N-terminal Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress DNA Replication-dependent Nucleosome Assembly Cellular Response To Heat N-terminal Protein Amino Acid Acetylation DNA Methylation On Cytosine Chromatin Silencing At RDNA Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Protein Stability N-terminal Protein Amino Acid Modification Notch Signaling Pathway Vesicle-mediated Transport Regulation Of Protein Binding Establishment Of Localization In Cell Intracellular Transport Response To Abiotic Stimulus Chromatin Silencing Placenta Blood Vessel Development Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Signal Transduction Response To Temperature Stimulus Positive Regulation Of Metabolic Process Response To Stress Posttranscriptional Regulation Of Gene Expression Histone H2B Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Neuromuscular Junction Development Regulation Of Metabolic Process Neuron Apoptotic Process Defense Response Cellular Localization Glutamate Receptor Signaling Pathway DNA Methylation Cellular Component Assembly Regulation Of Signaling Viral Process Neuron Death MAPK Import Into Nucleus Synaptic Growth At Neuromuscular Junction Polynucleotide 3' Dephosphorylation Vitellogenesis Regulation Of Binding Apoptotic Process Negative Regulation Of Gene Expression, Epigenetic Programmed Cell Death
Tagcloud ?		ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive	americans arg12his carm1 cataloging coding corepressor crebbp ep300 estrogens ethnic foxa1 hawaiians his52arg latinos mpg multiethnic ncoa1 ncoa2 ncoa3 ncor1 ncor2 nme1 nominally pparbp prmt1 smarca2 smarca4 steroid synonymous
Tagcloud (Difference) ?		ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive	americans arg12his carm1 cataloging coding corepressor crebbp ep300 estrogens ethnic foxa1 hawaiians his52arg latinos mpg multiethnic ncoa1 ncoa2 ncoa3 ncor1 ncor2 nme1 nominally pparbp prmt1 smarca2 smarca4 steroid synonymous
Tagcloud (Intersection) ?