GRB7 and DOCK7

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GRB7	DOCK7
Gene Name		growth factor receptor-bound protein 7	dedicator of cytokinesis 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection	Focal Adhesion COP9 Signalosome Axon Growth Cone Neuron Projection Basal Part Of Cell
	Molecular Function	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Rac GTPase Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Leukocyte Migration	Microtubule Cytoskeleton Organization Hematopoietic Progenitor Cell Differentiation Small GTPase Mediated Signal Transduction Axonogenesis Interkinetic Nuclear Migration Neuron Projection Development Activation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Pigmentation Establishment Of Neuroblast Polarity Regulation Of Neurogenesis
Pathways		Signaling by PDGF Signaling by SCF-KIT Signaling by ERBB2 Downstream signal transduction GRB7 events in ERBB2 signaling Tie2 Signaling Cell surface interactions at the vascular wall	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Cholesterol, total ( 19060911 20686565) LDL cholesterol ( 19060911 20686565) Metabolite levels ( 22916037) Triglycerides ( 18193044 20864672 19060911 20686565)
Protein-Protein Interactions		39 interactors: A1BG AGAP1 ATP5B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16	13 interactors: ANXA7 BCL2L1 CDC42 CDKN1A GRB7 PPP2CB RHOA RPP14 SMN1 SNCA TK1 WHSC1L1 YWHAG
Entrez ID		2886	85440
HPRD ID		03311	16833
Ensembl ID		ENSG00000141738	ENSG00000116641
Uniprot IDs		Q14451	Q96N67 Q96NI0
PDB IDs		1MW4 1WGR 2L4K 2QMS 3PQZ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Immune System Process Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Wound Healing Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Ketone Metabolic Process Regulation Of Catalytic Activity Regulation Of Immune System Process Regulation Of Signal Transduction Response To Wounding Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-amino Acid Modification Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Response To Hormone Regulation Of Cellular Protein Metabolic Process	Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Regulation Of Protein Localization Organelle Organization Hemostasis Response To Organic Cyclic Compound Response To Copper Ion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Inorganic Substance Apoptotic Process Response To Toxic Substance Response To Stress Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Death Death Substantia Nigra Development Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Response To External Stimulus Positive Regulation Of Cytokinesis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle Process Response To Growth Factor Cellular Response To Organic Substance Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Intracellular Protein Transport Positive Regulation Of Signal Transduction Mitotic Cell Cycle Process Neural Nucleus Development Cellular Response To Ionizing Radiation Positive Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Neuron Death Regulation Of Cytokinesis Regulation Of Signaling
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	2510dela 3709c 6232g 983c abolish arg1237 asp837alafs blindness dysmorphic encephalopathies epileptic exome gabaergic genesis glu2078 heterozygotes hyperintensities interneurons intractable nonconsanguineous pontobulbar proband rac sanger ser328 sisters sulcus syndromic truncating
Tagcloud (Difference) ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	2510dela 3709c 6232g 983c abolish arg1237 asp837alafs blindness dysmorphic encephalopathies epileptic exome gabaergic genesis glu2078 heterozygotes hyperintensities interneurons intractable nonconsanguineous pontobulbar proband rac sanger ser328 sisters sulcus syndromic truncating
Tagcloud (Intersection) ?