GRB7 and AGAP1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GRB7	AGAP1
Gene Name		growth factor receptor-bound protein 7	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection	Cytoplasm
	Molecular Function	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	GTP Binding Phospholipid Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Leukocyte Migration	Small GTPase Mediated Signal Transduction Protein Transport Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity
Pathways		Signaling by PDGF Signaling by SCF-KIT Signaling by ERBB2 Downstream signal transduction GRB7 events in ERBB2 signaling Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Menarche (age at onset) ( 23667675)
Protein-Protein Interactions		39 interactors: A1BG AGAP1 ATP5B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16	6 interactors: APP GRB7 GUCY1A3 GUCY1B3 SMN1 TK1
Entrez ID		2886	116987
HPRD ID		03311	16359
Ensembl ID		ENSG00000141738	ENSG00000157985
Uniprot IDs		Q14451	B2RZG9 Q9UPQ3
PDB IDs		1MW4 1WGR 2L4K 2QMS 3PQZ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Immune System Process Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Wound Healing Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Ketone Metabolic Process Regulation Of Catalytic Activity Regulation Of Immune System Process Regulation Of Signal Transduction Response To Wounding Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-amino Acid Modification Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Response To Hormone Regulation Of Cellular Protein Metabolic Process	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Nitric Oxide Mediated Signal Transduction CGMP Biosynthetic Process Response To Wounding CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Nucleotide Biosynthetic Process Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Nucleotide Metabolic Process Fetal Process Involved In Parturition Nucleobase-containing Small Molecule Metabolic Process Response To Defense-related Host Nitric Oxide Production Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Second-messenger-mediated Signaling Cellular Component Assembly Collateral Sprouting In Absence Of Injury Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleoprotein Complex Assembly Collateral Sprouting Axon Midline Choice Point Recognition Small Molecule Metabolic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Cortisol Thymidine Metabolic Process Organophosphate Metabolic Process Response To Host Immune Response Axon Choice Point Recognition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Regulation Of Translation Relaxation Of Vascular Smooth Muscle Cellular Nitrogen Compound Metabolic Process Ribonucleotide Metabolic Process Neuron Remodeling Relaxation Of Smooth Muscle Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Purine Nucleotide Metabolic Process Blood Circulation Ribose Phosphate Metabolic Process Phosphate-containing Compound Metabolic Process Ribonucleoprotein Complex Biogenesis
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Difference) ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Intersection) ?