KLHL35 and ALAS1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KLHL35	ALAS1
Gene Name		kelch-like family member 35	5-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function		5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding
	Biological Process		Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways			PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs			Pyridoxal Phosphate Glycine
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		4 interactors: ACVR1 ALAS1 APPBP2 TGFBR1	40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		283212	211
HPRD ID		08747	00505
Ensembl ID		ENSG00000149243	ENSG00000023330
Uniprot IDs		F5H412 Q6PF15	P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Pathway-restricted SMAD Protein Phosphorylation Pharyngeal System Development Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Development Endocardial Cushion Cell Fate Commitment Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchymal Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Ameboidal-type Cell Migration Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Heart Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Negative Regulation Of Apoptotic Signaling Pathway Signal Transduction By Phosphorylation Cell Fate Commitment Mitral Valve Morphogenesis Cardiac Muscle Cell Fate Commitment Stem Cell Differentiation Mitral Valve Development Embryonic Organ Morphogenesis Angiogenesis Positive Regulation Of Determination Of Dorsal Identity Parathyroid Gland Development Urogenital System Development Negative Regulation Of Activin Receptor Signaling Pathway Protoporphyrinogen IX Biosynthetic Process Atrial Septum Primum Morphogenesis Endocardial Cell Differentiation Septum Primum Development Blood Vessel Morphogenesis Endothelial Cell Activation Protoporphyrinogen IX Metabolic Process Pattern Specification Process Positive Regulation Of SMAD Protein Import Into Nucleus Embryonic Organ Development In Utero Embryonic Development Blood Vessel Development Heart Development Regulation Of SMAD Protein Import Into Nucleus Muscle Cell Fate Commitment Vasculature Development Germ Cell Migration	Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity
Tagcloud ?			adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Difference) ?			adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Intersection) ?