ALAS1 and CERK

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALAS1	CERK
Gene Name		5-aminolevulinate synthase 1	ceramide kinase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Mitochondrion Plasma Membrane Integral Component Of Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding	Magnesium Ion Binding Ceramide Kinase Activity NAD+ Kinase Activity Diacylglycerol Kinase Activity ATP Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Glycosphingolipid Metabolic Process Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Small Molecule Metabolic Process Lipid Phosphorylation Transmembrane Transport
Pathways		PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis	Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Orphan transporters
Drugs		Pyridoxal Phosphate Glycine
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	5 interactors: ALAS1 APP KRTAP10-3 MTUS2 NOTCH2NL
Entrez ID		211	64781
HPRD ID		00505	09878
Ensembl ID		ENSG00000023330	ENSG00000100422
Uniprot IDs		P13196 Q5JAM2	Q8TCT0
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity	Notch Signaling Pathway Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Protoporphyrinogen IX Biosynthetic Process Protoporphyrinogen IX Metabolic Process
Tagcloud ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	adriamycin aid arise ceramide clinicopathologic consequently deaths detectable disproportionately disseminated downregulation dtc dtcs engineered genetically incurable neoadjuvant neu pool prosurvival recurrence recurrent residual spontaneously substantially survive typically upregulated utility
Tagcloud (Difference) ?		adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2	adriamycin aid arise ceramide clinicopathologic consequently deaths detectable disproportionately disseminated downregulation dtc dtcs engineered genetically incurable neoadjuvant neu pool prosurvival recurrence recurrent residual spontaneously substantially survive typically upregulated utility
Tagcloud (Intersection) ?