ANG and ABCG8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ANG	ABCG8
Gene Name		angiogenin, ribonuclease, RNase A family, 5	ATP-binding cassette, sub-family G (WHITE), member 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Basal Lamina Extracellular Space Nucleus Nucleolus Growth Cone Angiogenin-PRI Complex Neuronal Cell Body Extracellular Vesicular Exosome	Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex
	Molecular Function	DNA Binding Actin Binding Endonuclease Activity Ribonuclease Activity Receptor Binding Copper Ion Binding Protein Binding Heparin Binding RRNA Binding Peptide Binding	Protein Binding ATP Binding ATPase Activity Cholesterol Transporter Activity Protein Heterodimerization Activity
	Biological Process	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Placenta Development Positive Regulation Of Endothelial Cell Proliferation Diacylglycerol Biosynthetic Process Cell Communication Activation Of Phospholipase C Activity RRNA Transcription Response To Hormone Cell Migration Negative Regulation Of Translation Actin Filament Polymerization Activation Of Protein Kinase B Activity Activation Of Phospholipase A2 Activity Positive Regulation Of Phosphorylation Homeostatic Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis	Response To Nutrient Excretion Negative Regulation Of Intestinal Phytosterol Absorption Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Response To Drug Cholesterol Homeostasis Small Molecule Metabolic Process Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport
Pathways			Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Lipid digestion, mobilization, and transport Trafficking of dietary sterols ABCA transporters in lipid homeostasis
Drugs		Pyrophosphate 2- Pyroglutamic Acid Citric Acid
Diseases
GWAS			Cholesterol, total ( 20686565) Gallstones ( 17632509) LDL cholesterol ( 23726366 19060906 20686565) Lipid metabolism phenotypes ( 19936222) Phytosterol levels ( 20529992)
Protein-Protein Interactions		8 interactors: ABCG8 ACTC1 ACTN2 ATP6AP1 PTEN RNH1 TDGF1 TNFSF8	8 interactors: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 NR4A1 NUPR1
Entrez ID		283	64241
HPRD ID		00105	05679
Ensembl ID		ENSG00000214274	ENSG00000143921
Uniprot IDs		P03950	Q9H221
PDB IDs		1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Tissue Development Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Striated Muscle Tissue Development Muscle Tissue Development Actin Filament-based Movement Negative Regulation Of Transport Endothelial Cell Migration Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Epithelial Cell Migration Epithelium Migration Response To Drug Heart Development Cardiac Muscle Cell Differentiation Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Activation Of APC-Cdc20 Complex Activity Postsynaptic Density Assembly Negative Regulation Of Presynaptic Membrane Organization Regulation Of Cell-matrix Adhesion Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Cardiocyte Differentiation Response To Ethanol Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Cell Death Negative Regulation Of Ribosome Biogenesis Central Nervous System Myelin Maintenance Positive Regulation Of Osteoclast Development Ameboidal-type Cell Migration Regulation Of Presynaptic Membrane Organization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell-substrate Adhesion Negative Regulation Of Dendritic Spine Development Microspike Assembly Rhythmic Synaptic Transmission Skeletal Muscle Thin Filament Assembly Activation Of Anaphase-promoting Complex Activity Synapse Maturation Muscle Contraction Response To Nutrient Cardiovascular System Development Striated Muscle Cell Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Intestinal Cholesterol Absorption Male Mating Behavior	Negative Regulation Of Lipid Transport Apoptotic Process Programmed Cell Death Cell Death Skeletal Muscle Cell Differentiation Death Positive Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Lipid Transport Neutral Lipid Metabolic Process Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Tissue Development Positive Regulation Of Epithelial Cell Proliferation Diacylglycerol Biosynthetic Process Activation Of Ral GTPase Activity Activation Of Phospholipase A2 Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Protein Modification Process Response To Hormone Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Gonad Development Regulation Of Protein Metabolic Process Development Of Primary Sexual Characteristics Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Translation Muscle Organ Development Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Protein Metabolic Process Sex Differentiation Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Cholesterol Transport Positive Regulation Of Fatty Acid Beta-oxidation CDP-diacylglycerol Biosynthetic Process Positive Regulation Of Vesicle Fusion Regulation Of Phospholipase A2 Activity Striated Muscle Tissue Development Positive Regulation Of Cellular Metabolic Process Regulation Of Female Gonad Development CDP-diacylglycerol Metabolic Process Lipid Digestion Positive Regulation Of Protein Transport Angiogenesis
Tagcloud ?		ace angiotensin b2 bk blockade blocker cbf circulation contributions converting dogs doppler enalaprilat icatibant intake intrarenal kallikrein kinin maintained mbf medullary micergrams micrograms needle probes renin salt upregulates vasodilatory	abca1 abcg5 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Difference) ?		ace angiotensin b2 bk blockade blocker cbf circulation contributions converting dogs doppler enalaprilat icatibant intake intrarenal kallikrein kinin maintained mbf medullary micergrams micrograms needle probes renin salt upregulates vasodilatory	abca1 abcg5 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Intersection) ?