ABCG8 and LMNB1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ABCG8	LMNB1
Gene Name		ATP-binding cassette, sub-family G (WHITE), member 8	lamin B1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex	Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Membrane
	Molecular Function	Protein Binding ATP Binding ATPase Activity Cholesterol Transporter Activity Protein Heterodimerization Activity	Structural Molecule Activity Phospholipase Binding
	Biological Process	Response To Nutrient Excretion Negative Regulation Of Intestinal Phytosterol Absorption Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Response To Drug Cholesterol Homeostasis Small Molecule Metabolic Process Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Pathways		Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Lipid digestion, mobilization, and transport Trafficking of dietary sterols ABCA transporters in lipid homeostasis	Apoptotic cleavage of cellular proteins DNA Damage/Telomere Stress Induced Senescence Mitotic Prophase Apoptotic execution phase Cellular Senescence Meiotic synapsis Depolymerisation of the Nuclear Lamina Nuclear Envelope Breakdown Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase M Phase Cell Cycle, Mitotic Formation of Senescence-Associated Heterochromatin Foci (SAHF) Programmed Cell Death Breakdown of the nuclear lamina Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Gallstones ( 17632509) LDL cholesterol ( 23726366 19060906 20686565) Lipid metabolism phenotypes ( 19936222) Phytosterol levels ( 20529992)	Parkinson's disease (motor and cognition) ( 22658654)
Protein-Protein Interactions		8 interactors: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 NR4A1 NUPR1	23 interactors: ABCG8 ATF4 CASP3 CASP6 CDK1 GIT2 GZMA GZMB LBR LMNA MBIP MELK PLEC PRKCA PRKCB PRKCD PRPH SERPINA3 SUMO4 TMPO TOR1AIP1 URB2 YWHAQ
Entrez ID		64241	4001
HPRD ID		05679	01036
Ensembl ID		ENSG00000143921	ENSG00000113368
Uniprot IDs		Q9H221	B4DZT3 P20700
PDB IDs			2KPW 3JT0 3TYY 3UMN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Lipid Transport Apoptotic Process Programmed Cell Death Cell Death Skeletal Muscle Cell Differentiation Death Positive Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Lipid Transport Neutral Lipid Metabolic Process Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Tissue Development Positive Regulation Of Epithelial Cell Proliferation Diacylglycerol Biosynthetic Process Activation Of Ral GTPase Activity Activation Of Phospholipase A2 Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Protein Modification Process Response To Hormone Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Gonad Development Regulation Of Protein Metabolic Process Development Of Primary Sexual Characteristics Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Translation Muscle Organ Development Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Protein Metabolic Process Sex Differentiation Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Cholesterol Transport Positive Regulation Of Fatty Acid Beta-oxidation CDP-diacylglycerol Biosynthetic Process Positive Regulation Of Vesicle Fusion Regulation Of Phospholipase A2 Activity Striated Muscle Tissue Development Positive Regulation Of Cellular Metabolic Process Regulation Of Female Gonad Development CDP-diacylglycerol Metabolic Process Lipid Digestion Positive Regulation Of Protein Transport Angiogenesis	Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Envelope Organization Execution Phase Of Apoptosis Apoptotic Signaling Pathway Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Nucleus Organization Peptidyl-threonine Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Histone H3-T6 Phosphorylation Positive Regulation Of Cell Death Cellular Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Histone Phosphorylation Peptidyl-amino Acid Modification Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Oxidative Stress Positive Regulation Of Catalytic Activity Endomembrane System Organization Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of MAP Kinase Activity Regulation Of Mitochondrion Organization Regulation Of Platelet Aggregation Membrane Organization Negative Regulation Of Glucose Transport Regulation Of Phosphorylation Regulation Of MAP Kinase Activity
Tagcloud ?		abca1 abcg5 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Difference) ?		abca1 abcg5 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Intersection) ?