ANG and PTEN

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ANG	PTEN
Gene Name		angiogenin, ribonuclease, RNase A family, 5	phosphatase and tensin homolog
Image
Gene Ontology Annotations	Cellular Component	Basal Lamina Extracellular Space Nucleus Nucleolus Growth Cone Angiogenin-PRI Complex Neuronal Cell Body Extracellular Vesicular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane PML Body Myelin Sheath Adaxonal Region Cell Projection Neuron Projection Dendritic Spine Schmidt-Lanterman Incisure Postsynaptic Membrane
	Molecular Function	DNA Binding Actin Binding Endonuclease Activity Ribonuclease Activity Receptor Binding Copper Ion Binding Protein Binding Heparin Binding RRNA Binding Peptide Binding	Magnesium Ion Binding Phosphatidylinositol-3-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Lipid Binding Anaphase-promoting Complex Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Enzyme Binding Protein Kinase Binding PDZ Domain Binding Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
	Biological Process	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Placenta Development Positive Regulation Of Endothelial Cell Proliferation Diacylglycerol Biosynthetic Process Cell Communication Activation Of Phospholipase C Activity RRNA Transcription Response To Hormone Cell Migration Negative Regulation Of Translation Actin Filament Polymerization Activation Of Protein Kinase B Activity Activation Of Phospholipase A2 Activity Positive Regulation Of Phosphorylation Homeostatic Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Angiogenesis Negative Regulation Of Protein Phosphorylation Regulation Of B Cell Apoptotic Process Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Apoptotic Process Activation Of APC-Cdc20 Complex Activity Epidermal Growth Factor Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Synapse Assembly Central Nervous System Development Heart Development Aging Response To Nutrient Learning Or Memory Memory Locomotory Behavior Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Response To Zinc Ion Regulation Of Neuron Projection Development Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Dentate Gyrus Development Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell Migration Negative Regulation Of Myelination Regulation Of Protein Stability Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Central Nervous System Myelin Maintenance Response To Estradiol Regulation Of Cellular Component Size Regulation Of Myeloid Cell Apoptotic Process Response To ATP Multicellular Organismal Response To Stress Social Behavior Peptidyl-tyrosine Dephosphorylation Fc-epsilon Receptor Signaling Pathway Response To Drug Maternal Behavior Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Endothelial Cell Migration Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Response To Ethanol Locomotor Rhythm Negative Regulation Of Cell Size Negative Regulation Of Organ Growth Response To Arsenic-containing Substance Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cardiac Muscle Tissue Development Forebrain Morphogenesis Brain Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phagocytosis Negative Regulation Of Axonogenesis Protein Stabilization T Cell Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Kinase B Signaling Rhythmic Synaptic Transmission Canonical Wnt Signaling Pathway Synapse Maturation Prepulse Inhibition Male Mating Behavior Long-term Synaptic Potentiation Long Term Synaptic Depression Prostate Gland Growth Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Ribosome Biogenesis Negative Regulation Of Cell Aging Negative Regulation Of Excitatory Postsynaptic Membrane Potential Presynaptic Membrane Assembly Postsynaptic Density Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Downstream TCR signaling Metabolism of lipids and lipoproteins Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Synthesis of PIPs at the plasma membrane Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Synthesis of IP3 and IP4 in the cytosol PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Phospholipid metabolism PI Metabolism Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Negative regulation of the PI3K/AKT network Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Inositol phosphate metabolism PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR TCR signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Pyrophosphate 2- Pyroglutamic Acid Citric Acid
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ABCG8 ACTC1 ACTN2 ATP6AP1 PTEN RNH1 TDGF1 TNFSF8	34 interactors: AKT1 ANG AR CAV1 CDC27 CHGB COPS6 CSNK2A1 CSNK2A2 DLG1 ESR1 FZR1 HBA1 LATS1 MAGI2 MAGI3 MAST1 MAST2 MAST3 MVP NDFIP1 NEDD4 PARK7 PPP1CA PXN SLC9A3R1 SLC9A3R2 STK11 TP53 UBE2I UBE2L3 USP13 UTP14A WWP1
Entrez ID		283	5728
HPRD ID		00105	03431
Ensembl ID		ENSG00000214274
Uniprot IDs		P03950	F6KD01 P60484
PDB IDs		1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36	1D5R 2KYL
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Tissue Development Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Striated Muscle Tissue Development Muscle Tissue Development Actin Filament-based Movement Negative Regulation Of Transport Endothelial Cell Migration Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Epithelial Cell Migration Epithelium Migration Response To Drug Heart Development Cardiac Muscle Cell Differentiation Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Activation Of APC-Cdc20 Complex Activity Postsynaptic Density Assembly Negative Regulation Of Presynaptic Membrane Organization Regulation Of Cell-matrix Adhesion Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Cardiocyte Differentiation Response To Ethanol Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Cell Death Negative Regulation Of Ribosome Biogenesis Central Nervous System Myelin Maintenance Positive Regulation Of Osteoclast Development Ameboidal-type Cell Migration Regulation Of Presynaptic Membrane Organization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell-substrate Adhesion Negative Regulation Of Dendritic Spine Development Microspike Assembly Rhythmic Synaptic Transmission Skeletal Muscle Thin Filament Assembly Activation Of Anaphase-promoting Complex Activity Synapse Maturation Muscle Contraction Response To Nutrient Cardiovascular System Development Striated Muscle Cell Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Intestinal Cholesterol Absorption Male Mating Behavior	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Negative Regulation Of Signaling Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Signal Transduction Cell Cycle Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Metabolic Process Positive Regulation Of Phosphorylation Mitotic Cell Cycle Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Cell Proliferation Mitotic Cell Cycle Negative Regulation Of Intracellular Signal Transduction Protein Complex Assembly Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Negative Regulation Of Protein Metabolic Process Cell Communication Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Catabolic Process Regulation Of Protein Ubiquitination Modification-dependent Protein Catabolic Process
Tagcloud ?		ace angiotensin b2 bk blockade blocker cbf circulation contributions converting dogs doppler enalaprilat icatibant intake intrarenal kallikrein kinin maintained mbf medullary micergrams micrograms needle probes renin salt upregulates vasodilatory	10q already ath aths atypical bax carcinogenesis ec ecs endometrial frequencies hyperplasias igfiir instability lead lesions lohs microsatellite msis mutated mutations pathogenesis precursor premalignant pursue putative rii simple tgf
Tagcloud (Difference) ?		ace angiotensin b2 bk blockade blocker cbf circulation contributions converting dogs doppler enalaprilat icatibant intake intrarenal kallikrein kinin maintained mbf medullary micergrams micrograms needle probes renin salt upregulates vasodilatory	10q already ath aths atypical bax carcinogenesis ec ecs endometrial frequencies hyperplasias igfiir instability lead lesions lohs microsatellite msis mutated mutations pathogenesis precursor premalignant pursue putative rii simple tgf
Tagcloud (Intersection) ?