IL37 and IL18R1

Number of citations of the paper that reports this interaction (PMID 12096920)
29

Data Source:
HPRD (in vitro)

		IL37	IL18R1
Gene Name		interleukin 37	interleukin 18 receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding	Receptor Activity Interleukin-1 Receptor Activity Protein Binding Interleukin-18 Receptor Activity
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway	Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Interferon-gamma Production Interleukin-18-mediated Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus T-helper 1 Cell Differentiation
Pathways
Drugs
Diseases
GWAS			Asthma ( 23028483 20860503 22561531) Atopic dermatitis ( 23042114) Celiac disease ( 20190752 18311140) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: CASP1 CASP4 IL18BP IL18R1 SMAD3	4 interactors: CD48 IL18 IL1RAP IL37
Entrez ID		27178	8809
HPRD ID		05695	05138
Ensembl ID		ENSG00000125571	ENSG00000115604
Uniprot IDs		Q9NZH6	B7ZKV7 Q13478
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production T-helper 1 Type Immune Response Regulation Of Inflammatory Response Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Production Immune Response Execution Phase Of Apoptosis Regulation Of Cytokine Production Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Transcription Factor Import Into Nucleus Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Transport Zymogen Activation Cellular Response To Organic Substance Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transforming Growth Factor Beta3 Production Interleukin-18-mediated Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Other Organism Positive Regulation Of Transport Positive Regulation Of Endopeptidase Activity Response To Biotic Stimulus Immune System Process Regulation Of Protein Localization Positive Regulation Of Peptidase Activity Cellular Response To Interleukin-18 Mitochondrial Depolarization Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Evasion Or Tolerance Of Host Defenses By Virus Response To Interleukin-18 Positive Regulation Of Interleukin-1 Alpha Secretion Apoptotic Process Regulation Of Protein Localization To Nucleus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Localization Regulation Of Nucleocytoplasmic Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly	Interleukin-2 Biosynthetic Process Interleukin-2 Production Cytokine Biosynthetic Process Cytokine Metabolic Process Defense Response Inflammatory Response Immune System Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Chemokine Biosynthetic Process Interleukin-13 Biosynthetic Process Cytokine Production Interferon-gamma Biosynthetic Process Response To Stress Positive Regulation Of NK T Cell Proliferation Immune Response Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Chemokine Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Chemokine Production Type 2 Immune Response Positive Regulation Of Interleukin-17 Production Cellular Response To Organic Substance Cytokine-mediated Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Sleep Interferon-gamma Production Cellular Response To Cytokine Stimulus Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Natural Killer Cell Activation Response To Organic Substance T-helper 1 Type Immune Response Positive Regulation Of Tissue Remodeling Response To Cytokine Regulation Of Activated T Cell Proliferation Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Natural Killer Cell Activation Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Response To Stimulus Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus
Tagcloud ?			affymetrix ancestry beyond ccr6 consortium crohn focusing genuine genuinely gwa harboring hits homologs humanhap550 il12 il12b il23 illumina reach replicated snp true trust tyk2 uncovered unleashing wellcome wtccc
Tagcloud (Difference) ?			affymetrix ancestry beyond ccr6 consortium crohn focusing genuine genuinely gwa harboring hits homologs humanhap550 il12 il12b il23 illumina reach replicated snp true trust tyk2 uncovered unleashing wellcome wtccc
Tagcloud (Intersection) ?