IL18R1 and CD48

Number of citations of the paper that reports this interaction (PMID 15760905)
5

Data Source:
HPRD (in vivo, in vitro)

		IL18R1	CD48
Gene Name		interleukin 18 receptor 1	CD48 molecule
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Interleukin-1 Receptor Activity Protein Binding Interleukin-18 Receptor Activity	Receptor Activity Protein Binding
	Biological Process	Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Interferon-gamma Production Interleukin-18-mediated Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus T-helper 1 Cell Differentiation	Defense Response Blood Coagulation Leukocyte Migration
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Asthma ( 23028483 20860503 22561531) Atopic dermatitis ( 23042114) Celiac disease ( 20190752 18311140) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		4 interactors: CD48 IL18 IL1RAP IL37	10 interactors: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK
Entrez ID		8809	962
HPRD ID		05138	00177
Ensembl ID		ENSG00000115604	ENSG00000117091
Uniprot IDs		B7ZKV7 Q13478	P09326
PDB IDs			2EDO
Enriched GO Terms of Interacting Partners?		Interleukin-2 Biosynthetic Process Interleukin-2 Production Cytokine Biosynthetic Process Cytokine Metabolic Process Defense Response Inflammatory Response Immune System Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Chemokine Biosynthetic Process Interleukin-13 Biosynthetic Process Cytokine Production Interferon-gamma Biosynthetic Process Response To Stress Positive Regulation Of NK T Cell Proliferation Immune Response Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Chemokine Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Chemokine Production Type 2 Immune Response Positive Regulation Of Interleukin-17 Production Cellular Response To Organic Substance Cytokine-mediated Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Sleep Interferon-gamma Production Cellular Response To Cytokine Stimulus Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Natural Killer Cell Activation Response To Organic Substance T-helper 1 Type Immune Response Positive Regulation Of Tissue Remodeling Response To Cytokine Regulation Of Activated T Cell Proliferation Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Natural Killer Cell Activation Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Response To Stimulus Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus	Regulation Of Defense Response To Virus By Virus Blood Coagulation Hemostasis Leukocyte Migration Regulation Of Body Fluid Levels Wound Healing T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation T Cell Costimulation Cell Activation Regulation Of T Cell Activation Regulation Of Defense Response To Virus Positive Regulation Of Cell Activation Immune System Process Response To Wounding Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Signal Transduction T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Signaling Antigen Receptor-mediated Signaling Pathway Cell Communication Regulation Of Cell Activation Leukocyte Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Platelet Activation Cellular Response To Stimulus Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Response To Stress Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Positive Regulation Of Intracellular Signal Transduction Cell Migration Natural Killer Cell Activation Cell Motility Positive Regulation Of Immune System Process
Tagcloud ?		affymetrix ancestry beyond ccr6 consortium crohn focusing genuine genuinely gwa harboring hits homologs humanhap550 il12 il12b il23 illumina reach replicated snp true trust tyk2 uncovered unleashing wellcome wtccc	advance cd150 cdd committed doi effector epo epor erythroblasts erythrocytes erythroid erythropoiesis erythropoietin h2afy2 highlighted hscs immunophenotypically lin macroh2a2 mh2a2 november phospholipase plcgamma1 progenitors publication recapitulated sca1 stat5a tightly
Tagcloud (Difference) ?		affymetrix ancestry beyond ccr6 consortium crohn focusing genuine genuinely gwa harboring hits homologs humanhap550 il12 il12b il23 illumina reach replicated snp true trust tyk2 uncovered unleashing wellcome wtccc	advance cd150 cdd committed doi effector epo epor erythroblasts erythrocytes erythroid erythropoiesis erythropoietin h2afy2 highlighted hscs immunophenotypically lin macroh2a2 mh2a2 november phospholipase plcgamma1 progenitors publication recapitulated sca1 stat5a tightly
Tagcloud (Intersection) ?