GGCX and F9

Number of citations of the paper that reports this interaction (PMID 11133752)
15

Data Source:
HPRD (in vivo)

		GGCX	F9
Gene Name		gamma-glutamyl carboxylase	coagulation factor IX
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Gamma-glutamyl Carboxylase Activity	Serine-type Endopeptidase Activity Calcium Ion Binding
	Biological Process	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Cellular Protein Metabolic Process	Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Coagulation, Extrinsic Pathway Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation of protein precursors Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Extrinsic Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation of protein precursors Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Coagulation factor VIIa Drotrecogin alfa Coagulation Factor IX L-Glutamic Acid Menadione Phytonadione Anisindione	Antihemophilic Factor Menadione
Diseases
GWAS		Prostate cancer ( 21743467)
Protein-Protein Interactions		6 interactors: BGLAP F10 F2 F7 F9 PROC	5 interactors: F2 F7 F8 GGCX LRP1
Entrez ID		2677	2158
HPRD ID		00665	02385
Ensembl ID		ENSG00000115486	ENSG00000101981
Uniprot IDs		P38435	P00740
PDB IDs			1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Extrinsic Pathway Post-translational Protein Modification Blood Coagulation, Intrinsic Pathway Blood Coagulation Hemostasis Protein Activation Cascade Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Vitamin K Peptidyl-amino Acid Modification Regulation Of Blood Coagulation Regulation Of Wound Healing Proteolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Positive Regulation Of Protein Kinase B Signaling Cellular Protein Modification Process Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Vitamin Response To Stress Regulation Of Protein Kinase B Signaling Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cellular Protein Metabolic Process Response To Estrogen Response To Nutrient Leukocyte Migration Response To Stimulus Response To Hydroxyisoflavone Negative Regulation Of Fibrinolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Protein Metabolic Process Regulation Of Fibrinolysis Negative Regulation Of Astrocyte Differentiation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Gravity Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Vitamin D Response To Nutrient Levels	Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Protein Activation Cascade Response To Wounding Blood Coagulation, Intrinsic Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Positive Regulation Of Blood Coagulation Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Blood Coagulation Beta-amyloid Clearance Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Response To Vitamin K Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification Platelet Activation Protein Metabolic Process Blood Coagulation, Extrinsic Pathway Response To Stress Negative Regulation Of Fibrinolysis Proteolysis Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Inflammatory Response Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Platelet Activation Positive Regulation Of Cholesterol Efflux Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Lipoprotein Transport Positive Regulation Of Cholesterol Transport Regulation Of Cholesterol Efflux Response To Stimulus Aorta Morphogenesis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Cell Migration Aorta Development Regulation Of Astrocyte Differentiation Fibrinolysis
Tagcloud ?			abundance achieved apparatus availability class contains decreases developmental differentiate dramatic embryogenesis embryonal endoderm feature find involves multisubunit murine parietal patterns polymerase regulation sl1 substantial tafi48 tafi95 tafs tata transcription
Tagcloud (Difference) ?			abundance achieved apparatus availability class contains decreases developmental differentiate dramatic embryogenesis embryonal endoderm feature find involves multisubunit murine parietal patterns polymerase regulation sl1 substantial tafi48 tafi95 tafs tata transcription
Tagcloud (Intersection) ?