GGCX and PROC

Number of citations of the paper that reports this interaction (PMID 1498334)
6

Data Source:
HPRD (in vitro)

		GGCX	PROC
Gene Name		gamma-glutamyl carboxylase	protein C (inactivator of coagulation factors Va and VIIIa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen
	Molecular Function	Gamma-glutamyl Carboxylase Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Cellular Protein Metabolic Process	Proteolysis Blood Coagulation Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Leukocyte Migration
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation of protein precursors Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Removal of aminoterminal propeptides from gamma-carboxylated proteins Gamma-carboxylation of protein precursors Formation of Fibrin Clot (Clotting Cascade) Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Coagulation factor VIIa Drotrecogin alfa Coagulation Factor IX L-Glutamic Acid Menadione Phytonadione Anisindione	Menadione Sodium Tetradecyl Sulfate
Diseases
GWAS		Prostate cancer ( 21743467)	Protein C levels ( 20802025)
Protein-Protein Interactions		6 interactors: BGLAP F10 F2 F7 F9 PROC	13 interactors: CP CSNK2B F2 F5 F8 GGCX PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		2677	5624
HPRD ID		00665	01466
Ensembl ID		ENSG00000115486	ENSG00000115718
Uniprot IDs		P38435	B4DPQ7 P04070
PDB IDs			1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Extrinsic Pathway Post-translational Protein Modification Blood Coagulation, Intrinsic Pathway Blood Coagulation Hemostasis Protein Activation Cascade Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Vitamin K Peptidyl-amino Acid Modification Regulation Of Blood Coagulation Regulation Of Wound Healing Proteolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Positive Regulation Of Protein Kinase B Signaling Cellular Protein Modification Process Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Vitamin Response To Stress Regulation Of Protein Kinase B Signaling Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cellular Protein Metabolic Process Response To Estrogen Response To Nutrient Leukocyte Migration Response To Stimulus Response To Hydroxyisoflavone Negative Regulation Of Fibrinolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Protein Metabolic Process Regulation Of Fibrinolysis Negative Regulation Of Astrocyte Differentiation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Gravity Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Vitamin D Response To Nutrient Levels	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Coagulation Platelet Activation Platelet Degranulation Leukocyte Migration Negative Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Response To Stress Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Exocytosis Locomotion Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Negative Regulation Of Platelet Activation Regulation Of Wound Healing Regulation Of Protein Processing Cell Migration Movement Of Cell Or Subcellular Component Cell Motility Fibrinolysis Secretion By Cell Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Post-translational Protein Modification Acute-phase Response Positive Regulation Of Coagulation Response To Stimulus Secretion Positive Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Fetal Process Involved In Parturition Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Acute Inflammatory Response Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Skeletal Muscle Cell Proliferation Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity
Tagcloud ?			a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang
Tagcloud (Difference) ?			a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang
Tagcloud (Intersection) ?