F9 and F7

Number of citations of the paper that reports this interaction (PMID 2248955)
18

Data Source:
HPRD (in vitro)

		F9	F7
Gene Name		coagulation factor IX	coagulation factor VII (serum prothrombin conversion accelerator)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding	Glycoprotein Binding Serine-type Endopeptidase Activity Receptor Binding Calcium Ion Binding Protein Binding Serine-type Peptidase Activity
	Biological Process	Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Coagulation, Extrinsic Pathway Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Cellular Protein Metabolic Process	Positive Regulation Of Leukocyte Chemotaxis Proteolysis Blood Coagulation Blood Coagulation, Extrinsic Pathway Circadian Rhythm Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-glutamic Acid Carboxylation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Organ Regeneration Response To Vitamin K Response To Estrogen Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Response To Growth Hormone
Pathways		Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Extrinsic Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation of protein precursors Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Post-translational protein modification Extrinsic Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation of protein precursors BMAL1:CLOCK,NPAS2 activates circadian gene expression Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Antihemophilic Factor Menadione	Coagulation factor VIIa Coagulation Factor IX Menadione (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2\'-HYDROXY-3\'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3\'-NITRO-BIPHENYL-3-YL]-ACETIC ACID
Diseases
GWAS			Factor VII ( 17903294) Prothrombin time ( 22703881)
Protein-Protein Interactions		5 interactors: F2 F7 F8 GGCX LRP1	7 interactors: ALB F10 F3 F9 GGCX HPN RCHY1
Entrez ID		2158	2155
HPRD ID		02385	01965
Ensembl ID		ENSG00000101981	ENSG00000057593
Uniprot IDs		P00740	B4DPM2 P08709
PDB IDs		1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5	1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1NL8 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Protein Activation Cascade Response To Wounding Blood Coagulation, Intrinsic Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Positive Regulation Of Blood Coagulation Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Blood Coagulation Beta-amyloid Clearance Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Response To Vitamin K Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification Platelet Activation Protein Metabolic Process Blood Coagulation, Extrinsic Pathway Response To Stress Negative Regulation Of Fibrinolysis Proteolysis Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Inflammatory Response Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Platelet Activation Positive Regulation Of Cholesterol Efflux Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Lipoprotein Transport Positive Regulation Of Cholesterol Transport Regulation Of Cholesterol Efflux Response To Stimulus Aorta Morphogenesis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Cell Migration Aorta Development Regulation Of Astrocyte Differentiation Fibrinolysis	Blood Coagulation, Extrinsic Pathway Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Blood Coagulation, Intrinsic Pathway Protein Activation Cascade Post-translational Protein Modification Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Activation Of Plasma Proteins Involved In Acute Inflammatory Response Proteolysis Regulation Of Protein Kinase B Signaling Maintenance Of Mitochondrion Location Activation Of Blood Coagulation Via Clotting Cascade Basement Membrane Disassembly Positive Regulation Of Behavior Positive Regulation Of Epithelial Cell Proliferation Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress Pilomotor Reflex Regulation Of Behavior Positive Regulation Of Plasminogen Activation Positive Regulation Of Hepatocyte Proliferation Regulation Of Thyroid Hormone Generation Peptidyl-amino Acid Modification Negative Regulation Of Alkaline Phosphatase Activity Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation By Host Of Viral Transcription Regulation Of Epithelial Cell Proliferation Positive Regulation Of Proteolysis Regulation Of Hepatocyte Proliferation Sodium-independent Organic Anion Transport Positive Regulation Of Cell Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Cell Motility Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Response To Thyroid Hormone Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Establishment Of Epithelial Cell Polarity Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm
Tagcloud ?		abundance achieved apparatus availability class contains decreases developmental differentiate dramatic embryogenesis embryonal endoderm feature find involves multisubunit murine parietal patterns polymerase regulation sl1 substantial tafi48 tafi95 tafs tata transcription	4e autoregulation betatc6 biosynthesis cap dependently dephosphorylation exert exogenous glucose immunosuppressant incubation insulin interacting islet islets latter mediate phas phosphatidylinositol phosphodiesterase rapamycin secreted serve stimulate stimulates theophylline translation wortmannin
Tagcloud (Difference) ?		abundance achieved apparatus availability class contains decreases developmental differentiate dramatic embryogenesis embryonal endoderm feature find involves multisubunit murine parietal patterns polymerase regulation sl1 substantial tafi48 tafi95 tafs tata transcription	4e autoregulation betatc6 biosynthesis cap dependently dephosphorylation exert exogenous glucose immunosuppressant incubation insulin interacting islet islets latter mediate phas phosphatidylinositol phosphodiesterase rapamycin secreted serve stimulate stimulates theophylline translation wortmannin
Tagcloud (Intersection) ?