GCH1 and SP3

Number of citations of the paper that reports this interaction (PMID 16696853)
9

Data Source:
BioGRID (two hybrid)

		GCH1	SP3
Gene Name		GTP cyclohydrolase 1	Sp3 transcription factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane PML Body Transcriptional Repressor Complex
	Molecular Function	GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Coenzyme Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Metabolic Process Regulation Of Blood Pressure Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Blood Pressure Nitric Oxide Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Protein Heterooligomerization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ossification Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter B Cell Differentiation T Cell Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis
Pathways		Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanine
Diseases
GWAS		Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		13 interactors: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ	19 interactors: E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF NKX3-1 PIAS1 RB1 RBBP4 SP1 STK19 SUMO1 TP53 UBE2I ZBTB7A
Entrez ID		2643	6670
HPRD ID		02573	03483
Ensembl ID		ENSG00000131979	ENSG00000172845
Uniprot IDs		P30793 Q8IZH9	B7ZLN9 Q02447 Q59FX5 Q86TP0
PDB IDs		1FB1
Enriched GO Terms of Interacting Partners?		Intracellular Transport Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Membrane Organization Intracellular Protein Transport Cellular Localization Positive Regulation Of ATPase Activity Regulation Of ATPase Activity Regulated Secretory Pathway Golgi Vesicle Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Negative Regulation Of Fibril Organization Negative Regulation Of GTP Cyclohydrolase I Activity Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling Protein Stabilization Positive Regulation Of Calcium:sodium Antiporter Activity Endomembrane System Organization Positive Regulation Of Potassium Ion Import Regulation Of Fibril Organization Protein Localization Secretion By Cell Golgi Reassembly Positive Regulation Of Sodium Ion Export From Cell Regulation Of Protein Stability Regulation Of Neurotransmitter Levels Regulation Of Metabolic Process Protein Transport Into Plasma Membrane Raft Clathrin Coat Disassembly Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Raft Histamine Secretion By Mast Cell Sodium Ion Export From Cell Establishment Of Golgi Localization Secretion Positive Regulation Of Metabolic Process Sodium Ion Export Golgi Inheritance Regulation Of Catalytic Activity Cellular Potassium Ion Homeostasis Vesicle-mediated Transport Histamine Secretion Transport Protein Transport Into Membrane Raft Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Plasma Membrane Organization Embryonic Process Involved In Female Pregnancy	Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Rhythmic Process RNA Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Chromatin Organization Regulation Of Signaling Response To Organic Substance Biosynthetic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signal Transduction Chromatin Modification Regulation Of Cell Cycle Chromatin Remodeling Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Substance Chromosome Organization Regulation Of Cell Proliferation Mitotic Cell Cycle Cellular Response To Hypoxia
Tagcloud ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Difference) ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Intersection) ?