GCH1 and RAB26

Number of citations of the paper that reports this interaction (PMID 16696853)
9

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GCH1	RAB26
Gene Name		GTP cyclohydrolase 1	RAB26, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein Complex	Golgi Membrane Endosome Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Coenzyme Binding	GTPase Activity Protein Binding GTP Binding GMP Binding GDP Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Metabolic Process Regulation Of Blood Pressure Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Blood Pressure Nitric Oxide Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Protein Heterooligomerization	Vesicle Docking Involved In Exocytosis Protein Secretion Regulation Of Exocytosis Rab Protein Signal Transduction Exocrine System Development Golgi To Plasma Membrane Protein Transport Regulated Secretory Pathway
Pathways		Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanine
Diseases
GWAS		Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		13 interactors: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ	3 interactors: APP GCH1 RIMS1
Entrez ID		2643	25837
HPRD ID		02573	05676
Ensembl ID		ENSG00000131979	ENSG00000167964
Uniprot IDs		P30793 Q8IZH9	B2RAA6 Q9ULW5
PDB IDs		1FB1	2G6B
Enriched GO Terms of Interacting Partners?		Intracellular Transport Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Membrane Organization Intracellular Protein Transport Cellular Localization Positive Regulation Of ATPase Activity Regulation Of ATPase Activity Regulated Secretory Pathway Golgi Vesicle Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Negative Regulation Of Fibril Organization Negative Regulation Of GTP Cyclohydrolase I Activity Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling Protein Stabilization Positive Regulation Of Calcium:sodium Antiporter Activity Endomembrane System Organization Positive Regulation Of Potassium Ion Import Regulation Of Fibril Organization Protein Localization Secretion By Cell Golgi Reassembly Positive Regulation Of Sodium Ion Export From Cell Regulation Of Protein Stability Regulation Of Neurotransmitter Levels Regulation Of Metabolic Process Protein Transport Into Plasma Membrane Raft Clathrin Coat Disassembly Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Raft Histamine Secretion By Mast Cell Sodium Ion Export From Cell Establishment Of Golgi Localization Secretion Positive Regulation Of Metabolic Process Sodium Ion Export Golgi Inheritance Regulation Of Catalytic Activity Cellular Potassium Ion Homeostasis Vesicle-mediated Transport Histamine Secretion Transport Protein Transport Into Membrane Raft Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Plasma Membrane Organization Embryonic Process Involved In Female Pregnancy	Neuromuscular Process Neurological System Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Lung Blood Pressure Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Dihydrobiopterin Metabolic Process Cellular Component Assembly Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Tetrahydrofolate Biosynthetic Process Neuron Remodeling Tetrahydrobiopterin Biosynthetic Process Secretion By Cell Dopamine Biosynthetic Process Regulation Of Inhibitory Postsynaptic Membrane Potential Nitric Oxide Biosynthetic Process Neuromuscular Process Controlling Posture Secretion Positive Regulation Of Nitric-oxide Synthase Activity Cellular Copper Ion Homeostasis Catecholamine Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Tetrahydrofolate Metabolic Process Positive Regulation Of Monooxygenase Activity Glutamate Secretion Positive Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Innate Immune Response Dopamine Metabolic Process Nitric Oxide Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Folic Acid-containing Compound Biosynthetic Process Reactive Nitrogen Species Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Mating Behavior Vasodilation Positive Regulation Of Excitatory Postsynaptic Membrane Potential Endoplasmic Reticulum Calcium Ion Homeostasis Membrane Hyperpolarization RNA Polyadenylation
Tagcloud ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val	aberrations adpkd array autosomal breakpoints cgh constitute contiguous deletions elucidation etc heterozygous immediately lies ligation mlpa monoallelic multiplex nthl1 outside pkd1 pkd2 pkdts polycystic proved tsc tsc1 tsc2 tuberous
Tagcloud (Difference) ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val	aberrations adpkd array autosomal breakpoints cgh constitute contiguous deletions elucidation etc heterozygous immediately lies ligation mlpa monoallelic multiplex nthl1 outside pkd1 pkd2 pkdts polycystic proved tsc tsc1 tsc2 tuberous
Tagcloud (Intersection) ?