GCH1 and AHSA1

Number of citations of the paper that reports this interaction (PMID 16696853)
9

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid)

		GCH1	AHSA1
Gene Name		GTP cyclohydrolase 1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein Complex	Cytoplasm Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome
	Molecular Function	GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Coenzyme Binding	ATPase Activator Activity Protein Binding Chaperone Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Metabolic Process Regulation Of Blood Pressure Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Blood Pressure Nitric Oxide Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Protein Heterooligomerization	Response To Stress Positive Regulation Of ATPase Activity
Pathways		Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanine
Diseases
GWAS		Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		13 interactors: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ	4 interactors: APP EGFR GCH1 HSP90AA1
Entrez ID		2643	10598
HPRD ID		02573	09768
Ensembl ID		ENSG00000131979	ENSG00000100591
Uniprot IDs		P30793 Q8IZH9	B4DUR9 O95433
PDB IDs		1FB1	1X53
Enriched GO Terms of Interacting Partners?		Intracellular Transport Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Membrane Organization Intracellular Protein Transport Cellular Localization Positive Regulation Of ATPase Activity Regulation Of ATPase Activity Regulated Secretory Pathway Golgi Vesicle Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Negative Regulation Of Fibril Organization Negative Regulation Of GTP Cyclohydrolase I Activity Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling Protein Stabilization Positive Regulation Of Calcium:sodium Antiporter Activity Endomembrane System Organization Positive Regulation Of Potassium Ion Import Regulation Of Fibril Organization Protein Localization Secretion By Cell Golgi Reassembly Positive Regulation Of Sodium Ion Export From Cell Regulation Of Protein Stability Regulation Of Neurotransmitter Levels Regulation Of Metabolic Process Protein Transport Into Plasma Membrane Raft Clathrin Coat Disassembly Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Raft Histamine Secretion By Mast Cell Sodium Ion Export From Cell Establishment Of Golgi Localization Secretion Positive Regulation Of Metabolic Process Sodium Ion Export Golgi Inheritance Regulation Of Catalytic Activity Cellular Potassium Ion Homeostasis Vesicle-mediated Transport Histamine Secretion Transport Protein Transport Into Membrane Raft Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Plasma Membrane Organization Embryonic Process Involved In Female Pregnancy	Regulation Of Nitric-oxide Synthase Activity Regulation Of Oxidoreductase Activity Reactive Oxygen Species Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Immune Response Reactive Nitrogen Species Metabolic Process Defense Response Axon Guidance Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Response To External Stimulus Regulation Of Reactive Oxygen Species Biosynthetic Process Axonogenesis Axon Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of ERBB Signaling Pathway Immune System Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Neuron Projection Development Alkanesulfonate Metabolic Process Cell Projection Morphogenesis Neuromuscular Process Cell Part Morphogenesis Regulation Of Reactive Oxygen Species Metabolic Process Neuron Development Regulation Of Lung Blood Pressure Synaptic Growth At Neuromuscular Junction Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Astrocyte Activation Cell Morphogenesis Response To Abiotic Stimulus Neuron Differentiation Positive Regulation Of Metabolic Process Cell Projection Organization Neurological System Process Regulation Of Peptidyl-tyrosine Phosphorylation Response To Stress Dihydrobiopterin Metabolic Process Collateral Sprouting In Absence Of Injury Establishment Of Protein Localization To Membrane Locomotion Activation Of Phospholipase A2 Activity
Tagcloud ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val	accurate alteration closeness collection comparative counterparts degree depth deregulation genomics herein hnrnpd integrative mouse nci offer offers oncogenic physiology proteasome ras representations signatures similarity spliceosome summary transformation underlining validating
Tagcloud (Difference) ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val	accurate alteration closeness collection comparative counterparts degree depth deregulation genomics herein hnrnpd integrative mouse nci offer offers oncogenic physiology proteasome ras representations signatures similarity spliceosome summary transformation underlining validating
Tagcloud (Intersection) ?