NPHP4 and RPGRIP1

Number of citations of the paper that reports this interaction (PMID 16339905)
32

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		NPHP4	RPGRIP1
Gene Name		nephronophthisis 4	retinitis pigmentosa GTPase regulator interacting protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Cell-cell Junction Tight Junction Membrane Photoreceptor Connecting Cilium Ciliary Transition Zone Ribbon Synapse Ciliary Base	Axoneme Photoreceptor Connecting Cilium
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding
	Biological Process	Organelle Organization Signal Transduction Visual Behavior Single Organismal Cell-cell Adhesion Actin Cytoskeleton Organization Sperm Motility Hippo Signaling Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway	Visual Perception Eye Photoreceptor Cell Development Response To Stimulus Retina Development In Camera-type Eye
Pathways		Signaling by Hippo Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		QT interval ( 19305408) Response to taxane treatment (placlitaxel) ( 23006423)
Protein-Protein Interactions		2 interactors: NPHP1 RPGRIP1	24 interactors: AEN BRCA1 CBX8 CCDC146 CHCHD3 CSPP1 DPPA4 FAM74A4 FEM1C GATAD2B HEYL IQCE MAGEB2 NPHP4 PTF1A RPGR RPP25L SCNM1 TBC1D7 TFPT TRIB3 ZNF337 ZNF417 ZNF564
Entrez ID		261734	57096
HPRD ID		06238	05673
Ensembl ID		ENSG00000131697	ENSG00000092200
Uniprot IDs		O75161 Q8IWC0	Q96KN7
PDB IDs
Enriched GO Terms of Interacting Partners?		Photoreceptor Cell Development Retina Development In Camera-type Eye Camera-type Eye Development Eye Development Photoreceptor Cell Outer Segment Organization Sensory Organ Development Neuron Development Neuron Differentiation Eye Photoreceptor Cell Development Excretion Eye Photoreceptor Cell Differentiation Generation Of Neurons Neurogenesis Tissue Development Visual Behavior Cell Development Nervous System Development Spermatid Differentiation Eye Morphogenesis Visual Perception Sensory Perception Of Light Stimulus Organ Development Cilium Organization	Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Lipid Biosynthetic Process Photoreceptor Cell Development Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Androgen Receptor Activity Negative Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Regulation Of Cellular Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Neural Retina Development Negative Regulation Of Cilium Assembly Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Eye Development Signal Transduction By P53 Class Mediator Amacrine Cell Differentiation Cellular Response To Indole-3-methanol
Tagcloud ?		5e 8e beadchip carbohydrate ckd clu cpg cric determining epigenetically filtration glomerular humanmethylation hypermethylated infinium ingenuity insufficiency iqsec1 islands kidney methylated networks nfkbib nfkbil2 nos3 slope tcf3 tgfb3 tgfbi	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp nphp1 nphp4 tgl throw ttl
Tagcloud (Difference) ?		5e 8e beadchip carbohydrate ckd clu cpg cric determining epigenetically filtration glomerular humanmethylation hypermethylated infinium ingenuity insufficiency iqsec1 islands kidney methylated networks nfkbib nfkbil2 nos3 slope tcf3 tgfb3 tgfbi	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp nphp1 tgl throw ttl
Tagcloud (Intersection) ?		nphp4