NPHP4 and NPHP1

Number of citations of the paper that reports this interaction (PMID 12244321)
50

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		NPHP4	NPHP1
Gene Name		nephronophthisis 4	nephronophthisis 1 (juvenile)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Cell-cell Junction Tight Junction Membrane Photoreceptor Connecting Cilium Ciliary Transition Zone Ribbon Synapse Ciliary Base	Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Tight Junction Membrane Motile Cilium Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Base
	Molecular Function	Structural Molecule Activity Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Organelle Organization Signal Transduction Visual Behavior Single Organismal Cell-cell Adhesion Actin Cytoskeleton Organization Sperm Motility Hippo Signaling Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway	Organelle Organization Signal Transduction Excretion Visual Behavior Single Organismal Cell-cell Adhesion Cell Projection Organization Actin Cytoskeleton Organization Cellular Protein Localization Photoreceptor Cell Outer Segment Organization Spermatid Differentiation Retina Development In Camera-type Eye
Pathways		Signaling by Hippo Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane	Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		QT interval ( 19305408) Response to taxane treatment (placlitaxel) ( 23006423)
Protein-Protein Interactions		2 interactors: NPHP1 RPGRIP1	15 interactors: ADAM15 ARHGAP32 BCAR1 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4
Entrez ID		261734	4867
HPRD ID		06238	09524
Ensembl ID		ENSG00000131697	ENSG00000144061
Uniprot IDs		O75161 Q8IWC0	B4DQY0 C9JNM7 O15259
PDB IDs			1S1N
Enriched GO Terms of Interacting Partners?		Photoreceptor Cell Development Retina Development In Camera-type Eye Camera-type Eye Development Eye Development Photoreceptor Cell Outer Segment Organization Sensory Organ Development Neuron Development Neuron Differentiation Eye Photoreceptor Cell Development Excretion Eye Photoreceptor Cell Differentiation Generation Of Neurons Neurogenesis Tissue Development Visual Behavior Cell Development Nervous System Development Spermatid Differentiation Eye Morphogenesis Visual Perception Sensory Perception Of Light Stimulus Organ Development Cilium Organization	Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament-based Process Cytoskeleton Organization Cellular Response To Stimulus Response To Stimulus Integrin-mediated Signaling Pathway Innate Immune Response Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Tissue Homeostasis Photoreceptor Cell Maintenance Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Junction Assembly Protein Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Developmental Process Multicellular Organismal Homeostasis Tissue Development Cell Differentiation Regulation Of Growth Cell Projection Organization Cell Development Positive Regulation Of Endothelial Cell Migration Epithelial To Mesenchymal Transition Cell Adhesion Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Retina Homeostasis Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Locomotion Regulation Of Wnt Signaling Pathway Actin Filament Organization Immune Response Positive Regulation Of Translation Anatomical Structure Development Mitotic Cell Cycle Defense Response Positive Regulation Of Epithelial Cell Migration Regulation Of Cell Growth
Tagcloud ?		5e 8e beadchip carbohydrate ckd clu cpg cric determining epigenetically filtration glomerular humanmethylation hypermethylated infinium ingenuity insufficiency iqsec1 islands kidney methylated networks nfkbib nfkbil2 nos3 slope tcf3 tgfb3 tgfbi	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp4 rpgrip1 rpgrip1l tgl throw ttl
Tagcloud (Difference) ?		5e 8e beadchip carbohydrate ckd clu cpg cric determining epigenetically filtration glomerular humanmethylation hypermethylated infinium ingenuity insufficiency iqsec1 islands kidney methylated networks nfkbib nfkbil2 nos3 slope tcf3 tgfb3 tgfbi	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis rpgrip1 rpgrip1l tgl throw ttl
Tagcloud (Intersection) ?		nphp4