CLIC4 and DNM1

Number of citations of the paper that reports this interaction (PMID 11563969)
25

Data Source:
HPRD (in vitro)

		CLIC4	DNM1
Gene Name		chloride intracellular channel 4	dynamin 1
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Mitochondrion Centrosome Cytosol Plasma Membrane Microvillus Cell-cell Junction Cell Surface Actin Cytoskeleton Microtubule Cytoskeleton Nuclear Matrix Midbody Cytoplasmic Vesicle Membrane Chloride Channel Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Microtubule Plasma Membrane Membrane Coat Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding	GTPase Activity Protein Binding GTP Binding Protein C-terminus Binding Protein Kinase Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding Nitric-oxide Synthase Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Chloride Transport Apoptotic Process Vacuolar Acidification Fertilization Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Multicellular Organism Growth Branching Morphogenesis Of An Epithelial Tube Regulation Of Cytoskeleton Organization Retina Vasculature Morphogenesis In Camera-type Eye Cellular Response To Calcium Ion Chloride Transmembrane Transport	Endocytosis Receptor-mediated Endocytosis Endosome Organization Axon Guidance Receptor Internalization Ephrin Receptor Signaling Pathway Clathrin-mediated Endocytosis
Pathways			Retrograde neurotrophin signalling Signalling by NGF Formation of annular gap junctions Axon guidance Gap junction degradation Gap junction trafficking L1CAM interactions NGF signalling via TRKA from the plasma membrane Recycling pathway of L1 Toll-Like Receptors Cascades EPH-ephrin mediated repulsion of cells Toll Like Receptor 4 (TLR4) Cascade Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Height ( 20881960)	Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		5 interactors: ACTB DNM1 HSP90AB1 REL YWHAZ	47 interactors: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CLIC3 CLIC4 CLINT1 CTTN DNM2 DNMBP EPS15 FNBP1 GNB2L1 GRB2 GRIN1 GRIN2D ITSN1 KIAA1377 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PRKCA PRNP SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SNAP25 SNX9 SRC SUMO1 TIMM50 UBE2I
Entrez ID		25932	1759
HPRD ID		05943	03851
Ensembl ID		ENSG00000169504	ENSG00000106976
Uniprot IDs		Q6FIC5 Q9Y696	Q05193
PDB IDs		2AHE 2D2Z 3OQS	1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS
Enriched GO Terms of Interacting Partners?		Immune Response Axon Guidance Defense Response Vesicle-mediated Transport Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Ephrin Receptor Signaling Pathway Neuron Projection Morphogenesis Endocytosis Cell Morphogenesis Involved In Differentiation Immune System Process Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Part Morphogenesis Signal Transduction Neuron Development Platelet Activation Negative Regulation Of Cell Death Negative Regulation Of Neuron Death Signaling Golgi Reassembly Cell Morphogenesis Cell Communication Positive Regulation Of Intracellular Transport Neuron Differentiation Cell Projection Organization Histamine Secretion By Mast Cell Phagocytosis Fc Receptor Signaling Pathway Establishment Of Golgi Localization Locomotion Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Folding Regulation Of Neuron Death Golgi Inheritance Cellular Response To Stimulus Histamine Secretion Response To Stress Movement Of Cell Or Subcellular Component Immune Response-regulating Cell Surface Receptor Signaling Pathway Histamine Transport Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Cell Death Generation Of Neurons	Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Positive Regulation Of Protein Complex Assembly Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Cellular Component Assembly Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Membrane Organization Transport Axon Guidance Cell Projection Organization Regulation Of Signaling Neuron Projection Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Complex Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemotaxis Synaptic Vesicle Transport Regulation Of Vesicle-mediated Transport Regulation Of Endocytosis Neuron Development Generation Of Neurons Membrane Tubulation Signaling Axonogenesis Anatomical Structure Development Protein Complex Assembly Neurogenesis Cell Communication Anatomical Structure Morphogenesis Locomotion Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Cell Morphogenesis Involved In Differentiation Axon Development Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Recycling Regulation Of Signal Transduction Neurotrophin Signaling Pathway Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Positive Regulation Of Metabolic Process Neuron Differentiation Negative Regulation Of Endocytosis
Tagcloud ?		antagonism antagonists atg5 atg7 attenuate autophagy blockade compromise ct414 decarboxylase fail h1r h2r h3r h3rs hdc histamine histidine ischaemia ischaemic knockout methyladenine neuroprotection protects reinforces reperfusion reversed suppressing tat	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		antagonism antagonists atg5 atg7 attenuate autophagy blockade compromise ct414 decarboxylase fail h1r h2r h3r h3rs hdc histamine histidine ischaemia ischaemic knockout methyladenine neuroprotection protects reinforces reperfusion reversed suppressing tat	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?