FNTB and RAP2A

Number of citations of the paper that reports this interaction (PMID 15451670)
58

Data Source:
HPRD (in vitro)

		FNTB	RAP2A
Gene Name		farnesyltransferase, CAAX box, beta	RAP2A, member of RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Farnesyltranstransferase Activity Protein Farnesyltransferase Activity Protein Binding Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Phototransduction, Visible Light Negative Regulation Of Cell Proliferation Response To Inorganic Substance Response To Organic Cyclic Compound Rhodopsin Mediated Signaling Pathway Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway Response To Cytokine Wound Healing Positive Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs			Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		9 interactors: CENPF FNTA GBP1 HDAC6 HRAS KRAS PTP4A3 RAP2A RRAS2	32 interactors: ACVR1 ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 MLLT4 NEDD4 PLG RAF1 RALA RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		2342	5911
HPRD ID		00608	01547
Ensembl ID		ENSG00000257365
Uniprot IDs		P49356	P10114
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Migration Response To Growth Factor Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Locomotion Regulation Of Synaptic Transmission, GABAergic Regulation Of Cellular Component Movement Regulation Of Rac Protein Signal Transduction Social Behavior Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Neuron Death Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Light Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Response To External Stimulus Positive Regulation Of Locomotion Visual Behavior Activation Of MAPKK Activity Lung Morphogenesis Cellular Response To Organic Substance Regulation Of Oxidoreductase Activity Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Associative Learning Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Muscle Structure Development Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Receptor Activity Cell Communication Cellular Response To Growth Factor Stimulus Response To Organic Substance Learning Actin Cytoskeleton Organization	Intracellular Signal Transduction Response To Stimulus Regulation Of Signaling Regulation Of Catalytic Activity Cell Communication Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Rap GTPase Activity Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Rap Protein Signal Transduction Signal Transduction By Phosphorylation Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Ras Protein Signal Transduction Regulation Of Dendrite Morphogenesis Response To Wounding Regulation Of Cell Projection Organization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Platelet Activation Regulation Of Ras GTPase Activity Cellular Response To Growth Factor Stimulus Response To Organic Substance Regulation Of Cellular Process Response To Growth Factor Regulation Of Dendrite Development Cardiovascular System Development Cell Surface Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cellular Localization Cell Differentiation Blood Vessel Development Response To Stress Vasculature Development Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Activation Of MAPKK Activity
Tagcloud ?		annotation atad5 automatically becn1 cdkn2a centered clusterone cytoscape david e2f e2f1 geneways kegg kras language module modules mp neurofibromatosis nf1 nf2 nsclc orthologous phenotypes proven successively systemically thyroglobulin visualization	cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Difference) ?		annotation atad5 automatically becn1 cdkn2a centered clusterone cytoscape david e2f e2f1 geneways kegg kras language module modules mp neurofibromatosis nf1 nf2 nsclc orthologous phenotypes proven successively systemically thyroglobulin visualization	cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Intersection) ?