PAXIP1 and DNAJB11

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PAXIP1	DNAJB11
Gene Name		PAX interacting (with transcription-activation domain) protein 1	DnaJ (Hsp40) homolog, subfamily B, member 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Histone Methyltransferase Complex	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane
	Molecular Function	Protein Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis DNA Repair DNA Recombination Transcription, DNA-templated Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Endothelial Cell Migration Positive Regulation Of Isotype Switching Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development	Protein Folding Activation Of Signaling Protein Activity Involved In Unfolded Protein Response MRNA Modification Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process
Pathways			IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: A2M APP ATHL1 ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CLU COMTD1 CRIPAK CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FAM96B FBLN5 FUCA1 H2AFX HIST1H3A HNRNPLL HSPA14 HSPA4L INTS7 LACTB LOC653602 MAPRE2 MAST1 MRPL33 MT2A MTIF3 ND1 NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 ZBTB8A ZNF251 ZNF280B	23 interactors: ANKZF1 APOBEC1 BAG6 CEP70 COL6A1 CRMP1 DDAH2 DNAJC13 DRAP1 EIF3D EZH2 FAF1 GRB2 HSPA1A PAXIP1 PTN SIMC1 SNX5 SPRED1 SUMO4 UBQLN4 UBR1 ZZZ3
Entrez ID		22976	51726
HPRD ID		08491	07485
Ensembl ID		ENSG00000157212	ENSG00000090520
Uniprot IDs		Q6ZW49	Q9UBS4
PDB IDs		3SQD
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Localization Signal Transduction By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Localization Cellular Response To DNA Damage Stimulus Intracellular Receptor Signaling Pathway Gene Expression Spermatogenesis Heterocycle Metabolic Process Male Gamete Generation Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Cellular Response To Stress Blood Coagulation DNA Damage Checkpoint Hemostasis Protein Stabilization Translational Initiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Body Fluid Levels Cellular Metabolic Process Reproductive Process Establishment Of Localization In Cell Positive Regulation Of Potassium Ion Import DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest RNA Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Response To Stimulus Signal Transduction Involved In Cell Cycle Checkpoint Gamete Generation Regulation Of Protein Ubiquitination Positive Regulation Of Sodium Ion Export From Cell Sexual Reproduction Regulation Of Cellular Protein Metabolic Process Catabolic Process Mitotic Cell Cycle Process Viral Process Platelet Degranulation Regulation Of Protein Stability Positive Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest	Peptidyl-lysine Modification Catabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signal Transduction Response To Ionizing Radiation Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Regulation Of Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Cellular Response To Amino Acid Stimulus Cellular Heat Acclimation Regulation Of Early Endosome To Recycling Endosome Transport Cytidine To Uridine Editing Cellular Response To Leucine Formation Of Cytoplasmic Translation Initiation Complex Ossification Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Methylation-dependent Chromatin Silencing DNA Modification Positive Regulation Of Reactive Oxygen Species Metabolic Process Histone Lysine Methylation Protein Stabilization Regulation Of Protein Complex Assembly Chromatin Organization Signal Transduction In Response To DNA Damage Peptidyl-lysine Methylation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Regulation Of Methylation-dependent Chromatin Silencing Locomotion Regulation Of Protein Catabolic Process Axon Guidance Signal Transduction By P53 Class Mediator Response To Amino Acid
Tagcloud ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	aggregation attenuates chaperoning clients destabilized erdj3 evade extracellular hsp40 indirectly influences links metazoan misfolded overwhelmed preemptively prion prone proteostasis proteotoxic proteotoxicity remodeling revealing secrete secretion space substoichiometrically unfolded upr
Tagcloud (Difference) ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk	aggregation attenuates chaperoning clients destabilized erdj3 evade extracellular hsp40 indirectly influences links metazoan misfolded overwhelmed preemptively prion prone proteostasis proteotoxic proteotoxicity remodeling revealing secrete secretion space substoichiometrically unfolded upr
Tagcloud (Intersection) ?