DNAJB11 and UBR1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		DNAJB11	UBR1
Gene Name		DnaJ (Hsp40) homolog, subfamily B, member 11	ubiquitin protein ligase E3 component n-recognin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane	Ubiquitin Ligase Complex Proteasome Complex Cytosol
	Molecular Function	Protein Binding Unfolded Protein Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Leucine Binding
	Biological Process	Protein Folding Activation Of Signaling Protein Activity Involved In Unfolded Protein Response MRNA Modification Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ANKZF1 APOBEC1 BAG6 CEP70 COL6A1 CRMP1 DDAH2 DNAJC13 DRAP1 EIF3D EZH2 FAF1 GRB2 HSPA1A PAXIP1 PTN SIMC1 SNX5 SPRED1 SUMO4 UBQLN4 UBR1 ZZZ3	26 interactors: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBC UBE2A UBE2B
Entrez ID		51726	197131
HPRD ID		07485	09342
Ensembl ID		ENSG00000090520	ENSG00000159459
Uniprot IDs		Q9UBS4	Q8IWV7
PDB IDs			3NY1
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Modification Catabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signal Transduction Response To Ionizing Radiation Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Regulation Of Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Cellular Response To Amino Acid Stimulus Cellular Heat Acclimation Regulation Of Early Endosome To Recycling Endosome Transport Cytidine To Uridine Editing Cellular Response To Leucine Formation Of Cytoplasmic Translation Initiation Complex Ossification Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Methylation-dependent Chromatin Silencing DNA Modification Positive Regulation Of Reactive Oxygen Species Metabolic Process Histone Lysine Methylation Protein Stabilization Regulation Of Protein Complex Assembly Chromatin Organization Signal Transduction In Response To DNA Damage Peptidyl-lysine Methylation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Regulation Of Methylation-dependent Chromatin Silencing Locomotion Regulation Of Protein Catabolic Process Axon Guidance Signal Transduction By P53 Class Mediator Response To Amino Acid	Response To Stimulus Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Cellular Localization Cellular Response To Stimulus Regulation Of Kinase Activity Establishment Of Localization In Cell Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Cell Cycle Signaling Intracellular Signal Transduction Regulation Of Catalytic Activity Cellular Response To Organic Substance Cell Communication Regulation Of Cellular Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stress Response To Radiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Process Regulation Of Cell Death Signal Transduction Regulation Of ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Immune System Process Histone H2A Ubiquitination Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity
Tagcloud ?		aggregation attenuates chaperoning clients destabilized erdj3 evade extracellular hsp40 indirectly influences links metazoan misfolded overwhelmed preemptively prion prone proteostasis proteotoxic proteotoxicity remodeling revealing secrete secretion space substoichiometrically unfolded upr	26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Difference) ?		aggregation attenuates chaperoning clients destabilized erdj3 evade extracellular hsp40 indirectly influences links metazoan misfolded overwhelmed preemptively prion prone proteostasis proteotoxic proteotoxicity remodeling revealing secrete secretion space substoichiometrically unfolded upr	26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Intersection) ?