PAXIP1 and MTIF3

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		PAXIP1	MTIF3
Gene Name		PAX interacting (with transcription-activation domain) protein 1	mitochondrial translational initiation factor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Histone Methyltransferase Complex	Mitochondrion
	Molecular Function	Protein Binding	Translation Initiation Factor Activity Translation Factor Activity, Nucleic Acid Binding Ribosomal Small Subunit Binding
	Biological Process	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis DNA Repair DNA Recombination Transcription, DNA-templated Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Endothelial Cell Migration Positive Regulation Of Isotype Switching Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development	Organelle Organization Mitochondrial Translation Ribosome Disassembly Mitochondrial Translational Initiation
Pathways			Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation initiation
Drugs
Diseases
GWAS			Body mass index ( 20935630)
Protein-Protein Interactions		91 interactors: A2M APP ATHL1 ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CLU COMTD1 CRIPAK CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FAM96B FBLN5 FUCA1 H2AFX HIST1H3A HNRNPLL HSPA14 HSPA4L INTS7 LACTB LOC653602 MAPRE2 MAST1 MRPL33 MT2A MTIF3 ND1 NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 ZBTB8A ZNF251 ZNF280B	3 interactors: MAPK1 PAXIP1 SIAH1
Entrez ID		22976	219402
HPRD ID		08491	17609
Ensembl ID		ENSG00000157212	ENSG00000122033
Uniprot IDs		Q6ZW49	Q9H2K0
PDB IDs		3SQD
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Localization Signal Transduction By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Localization Cellular Response To DNA Damage Stimulus Intracellular Receptor Signaling Pathway Gene Expression Spermatogenesis Heterocycle Metabolic Process Male Gamete Generation Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Cellular Response To Stress Blood Coagulation DNA Damage Checkpoint Hemostasis Protein Stabilization Translational Initiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Body Fluid Levels Cellular Metabolic Process Reproductive Process Establishment Of Localization In Cell Positive Regulation Of Potassium Ion Import DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest RNA Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Response To Stimulus Signal Transduction Involved In Cell Cycle Checkpoint Gamete Generation Regulation Of Protein Ubiquitination Positive Regulation Of Sodium Ion Export From Cell Sexual Reproduction Regulation Of Cellular Protein Metabolic Process Catabolic Process Mitotic Cell Cycle Process Viral Process Platelet Degranulation Regulation Of Protein Stability Positive Regulation Of Cell Cycle Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest	Regulation Of Protein Stability Positive Regulation Of Histone H3-K36 Methylation Locomotion MAPK Import Into Nucleus Movement Of Cell Or Subcellular Component Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Cytosine Metabolic Process Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Golgi Organization Chorion Development Posttranscriptional Regulation Of Gene Expression Anatomical Structure Morphogenesis Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Regulation Of Cellular Ketone Metabolic Process Blood Vessel Development Regulation Of Early Endosome To Late Endosome Transport Axonogenesis Vasculature Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Chemotaxis Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Immune Response Neuron Projection Morphogenesis Positive Regulation Of DNA-templated Transcription, Initiation ERK1 And ERK2 Cascade Cellular Protein Modification Process Positive Regulation Of Histone Acetylation Cell Morphogenesis Involved In Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of DNA-templated Transcription, Initiation Mammary Gland Epithelial Cell Proliferation Regulation Of Histone H3-K4 Methylation Protein Destabilization Positive Regulation Of Peptidyl-lysine Acetylation Cell Differentiation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Isotype Switching Positive Regulation Of Protein Acetylation Cellular Response To Growth Hormone Stimulus Labyrinthine Layer Blood Vessel Development Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Cell Projection Morphogenesis
Tagcloud ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk
Tagcloud (Difference) ?		amnion axial bmp2 chorion chorionic cognate ectoderm endodermal extraembryonic fail gastrulation mesodermal methyltransferases mll3 mll4 neuroectodermal originally pa1 pagr1 pagr1a patterning predominately pregastrulation rotation sac somite visceral yolk
Tagcloud (Intersection) ?