SHANK2 and SLC9A3

Number of citations of the paper that reports this interaction (PMID 16293618)
11

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SHANK2	SLC9A3
Gene Name		SH3 and multiple ankyrin repeat domains 2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Cell Junction Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Plasma Membrane Brush Border Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding	Protein Binding Sodium:proton Antiporter Activity PDZ Domain Binding
	Biological Process	Synapse Assembly Learning Memory Adult Behavior Social Behavior Exploration Behavior Long-term Synaptic Potentiation Long Term Synaptic Depression Vocalization Behavior	Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Transmembrane Transport Hydrogen Ion Transmembrane Transport
Pathways			Sodium/Proton exchangers Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075)	Ulcerative colitis ( 23128233)
Protein-Protein Interactions		15 interactors: ARHGEF7 BAI2 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 LPHN1 LPHN2 SHARPIN SLC9A3 SSTR2	8 interactors: CHP1 CHP2 LRP2 MAST2 PDZK1 SHANK2 SLC9A3R1 SLC9A3R2
Entrez ID		22941	6550
HPRD ID		04479	01660
Ensembl ID		ENSG00000162105	ENSG00000066230
Uniprot IDs		C0SPH0 Q9UPX8	P48764
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Signaling Cell Communication Synaptic Transmission Nervous System Development Neuron Projection Morphogenesis Dendritic Spine Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cell Morphogenesis Focal Adhesion Assembly Neuron Development Cell Morphogenesis Adherens Junction Assembly Lamellipodium Organization Neuron Differentiation Cell-substrate Junction Assembly Cell Projection Organization Endocytosis Regulation Of Cellular Component Organization Regulation Of Axon Extension Negative Regulation Of Membrane Tubulation Post-Golgi Vesicle-mediated Transport Adherens Junction Organization System Development Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Positive Regulation Of Lamellipodium Morphogenesis Generation Of Neurons Synaptic Vesicle Transport Neurogenesis Somatostatin Signaling Pathway Regulation Of Cell Size Regulation Of Cell Projection Organization Dendrite Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Cell Development Multicellular Organismal Development Axonogenesis Maintenance Of Apical/basal Cell Polarity Regulation Of Lamellipodium Morphogenesis Regulation Of Axonogenesis Regulation Of Synaptic Plasticity Cellular Component Assembly G-protein Coupled Receptor Signaling Pathway Anatomical Structure Development Receptor Localization To Synapse Dendritic Spine Maintenance	Regulation Of Sodium:proton Antiporter Activity Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Proton Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Intracellular Protein Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Sodium Ion Transport Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Intracellular Transport Renal Phosphate Ion Absorption Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatase Activity Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of Dephosphorylation Monocarboxylic Acid Transport Regulation Of Protein Transport Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Monovalent Inorganic Cation Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Protein Glycosylation Regulation Of Protein Import Into Nucleus Positive Regulation Of Transport Regulation Of Signaling Renal Sodium Ion Transport Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Ion Transport Cellular Component Assembly Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Sodium Ion Transmembrane Transport Protein Localization
Tagcloud ?		acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet	1p11 1q42 allows approximate assigned candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely
Tagcloud (Difference) ?		acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet	1p11 1q42 allows approximate assigned candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely
Tagcloud (Intersection) ?