SIRT2 and SP140

Number of citations of the paper that reports this interaction (PMID 12887892)
140

Data Source:
HPRD (in vivo)

		SIRT2	SP140
Gene Name		sirtuin 2	SP140 nuclear body protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Chromatin Silencing Complex Chromosome Nuclear Heterochromatin Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Plasma Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm PML Body
	Molecular Function	Chromatin Binding NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Beta-tubulin Binding NAD+ Binding	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Chromatin Silencing Chromatin Silencing At Telomere Transcription, DNA-templated Protein ADP-ribosylation Protein Deacetylation Autophagy Mitotic Nuclear Division Regulation Of Exit From Mitosis Negative Regulation Of Cell Proliferation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Phosphatidylinositol 3-kinase Signaling Gene Silencing Histone Deacetylation Substantia Nigra Development Myelination In Peripheral Nervous System Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Protein Kinase B Signaling Cellular Lipid Catabolic Process Innate Immune Response Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Hepatocyte Growth Factor Receptor Signaling Pathway Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Caloric Restriction Negative Regulation Of Oligodendrocyte Progenitor Proliferation Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Molecule Of Bacterial Origin Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Defense Response To Bacterium Ripoptosome Assembly Involved In Necroptotic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia	Chromatin Remodeling Regulation Of Transcription, DNA-templated Defense Response
Pathways
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461) Crohn's disease ( 21102463 23128233) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		13 interactors: CDC14B CDC20 EP300 FZR1 HDAC6 HIST1H3A HOXA10 KAT2A KAT2B SP140 TUBA4A TUBB XPO1	1 interactors: SIRT2
Entrez ID		22933	11262
HPRD ID		10377	09780
Ensembl ID		ENSG00000068903	ENSG00000079263
Uniprot IDs		Q8IXJ6	B4DVW8 E7ESH9 E7EUR5 E9PFJ6 Q0VGE4 Q13342 Q3KR17 Q8IWJ1
PDB IDs		1J8F 3ZGO 3ZGV
Enriched GO Terms of Interacting Partners?		Activation Of Anaphase-promoting Complex Activity Cell Cycle Organelle Organization Cell Cycle Process N-terminal Peptidyl-lysine Acetylation Chromatin Organization Mitotic Cell Cycle Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ubiquitin-protein Transferase Activity Chromosome Organization Peptidyl-lysine Modification Positive Regulation Of Ligase Activity Chromatin Modification Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Metabolic Process N-terminal Protein Amino Acid Acetylation Mitotic Cell Cycle Process Histone Acetylation G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Positive Regulation Of Gluconeogenesis Negative Regulation Of Cellular Metabolic Process Histone Modification Protein Acetylation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Cycle N-terminal Protein Amino Acid Modification Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Response To Stress Chromatin Remodeling Positive Regulation Of Glucose Metabolic Process G2 DNA Damage Checkpoint Viral Process Regulation Of Protein Ubiquitination Histone H3-K9 Modification Cell Cycle Checkpoint Regulation Of Meiosis Histone H3 Acetylation Regulation Of Gluconeogenesis Anterior/posterior Pattern Specification Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition	Negative Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Defense Response To Bacterium Cellular Response To Caloric Restriction Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia Chromatin Silencing At Telomere Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Defense Response To Bacterium Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Oocyte Maturation Tubulin Deacetylation Peptidyl-lysine Deacetylation Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Oocyte Development Positive Regulation Of Chromosome Segregation Regulation Of Exit From Mitosis Cellular Response To Epinephrine Stimulus Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Meiotic Nuclear Division Response To Epinephrine Response To Redox State Chromatin Silencing At RDNA Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Execution Phase Of Apoptosis Cellular Response To Catecholamine Stimulus Phosphatidylinositol 3-kinase Signaling Histone H4 Deacetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Necroptotic Process Protein ADP-ribosylation Histone H3 Deacetylation Positive Regulation Of DNA Binding Negative Regulation Of Autophagy Chromatin Silencing Regulation Of Meiosis Substantia Nigra Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Kinase B Signaling Programmed Necrotic Cell Death Myelination In Peripheral Nervous System Necrotic Cell Death Schwann Cell Development Regulation Of Myelination Negative Regulation Of Neural Precursor Cell Proliferation
Tagcloud ?		3t3 acbd3 acetylated acetylation acyl adipocytes anchoring cargos coa comprising deacetylated disposal endosomes enhances exocytic glut4 golgin gsv gsvs irap l1 nad recycles redistributed triggers tug unstimulated vesicles wildtype	biliary binders bromodomain catalyzes cirrhosis diversified elusive expand finger fingers flag homeodomain isomerase isomerization l3 leukocyte list lymphocytic modules peptidylprolyl phd phosphopeptide pin1 platforms pthr reader sand tails versatile
Tagcloud (Difference) ?		3t3 acbd3 acetylated acetylation acyl adipocytes anchoring cargos coa comprising deacetylated disposal endosomes enhances exocytic glut4 golgin gsv gsvs irap l1 nad recycles redistributed triggers tug unstimulated vesicles wildtype	biliary binders bromodomain catalyzes cirrhosis diversified elusive expand finger fingers flag homeodomain isomerase isomerization l3 leukocyte list lymphocytic modules peptidylprolyl phd phosphopeptide pin1 platforms pthr reader sand tails versatile
Tagcloud (Intersection) ?